Dye decolorizing peroxidase

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Dye-decolorizing peroxidase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Dye-decolorizing peroxidase (EC, DyP, DyP-type peroxidase) is an enzyme with systematic name Reactive-Blue-5:hydrogen-peroxide oxidoreductase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction

Reactive Blue 5 + H2O2 phthalate + 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate

These heme proteins are secreted by basidiomycetous fungi and eubacteria.


  1. ^ Kim, S.J.; Shoda, M. (1999). "Purification and characterization of a novel peroxidase from Geotrichum candidum dec 1 involved in decolorization of dyes". Appl. Environ. Microbiol. 65 (3): 1029–1035. PMC 91140Freely accessible. PMID 10049859. 
  2. ^ Sugano, Y.; Ishii, Y.; Shoda, M. (2004). "Role of H164 in a unique dye-decolorizing heme peroxidase DyP". Biochem. Biophys. Res. Commun. 322 (1): 126–132. doi:10.1016/j.bbrc.2004.07.090. PMID 15313183. 
  3. ^ Zubieta, C.; Joseph, R.; Krishna, S.S.; McMullan, D.; Kapoor, M.; Axelrod, H.L.; Miller, M.D.; Abdubek, P.; Acosta, C.; Astakhova, T.; Carlton, D.; Chiu, H.J.; Clayton, T.; Deller, M.C.; Duan, L.; Elias, Y.; Elsliger, M.A.; Feuerhelm, J.; Grzechnik, S.K.; Hale, J.; Han, G.W.; Jaroszewski, L.; Jin, K.K.; Klock, H.E.; Knuth, M.W.; Kozbial, P.; Kumar, A.; Marciano, D.; Morse, A.T.; Murphy, K.D.; Nigoghossian, E.; Okach, L.; Oommachen, S.; Reyes, R.; Rife, C.L.; Schimmel, P.; Trout, C.V.; van den Bedem, H.; Weekes, D.; White, A.; Xu, Q.; Hodgson, K.O.; Wooley, J.; Deacon A.M.; Godzik, A.; Lesley, S.A.; Wilson, I.A. (2007). "Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA". Proteins. 69: 234–243. doi:10.1002/prot.21673. PMID 17654547. 
  4. ^ Sugano, Y.; Matsushima, Y.; Tsuchiya, K.; Aoki, H.; Hirai, M.; Shoda, M. (2009). "Degradation pathway of an anthraquinone dye catalyzed by a unique peroxidase DyP from Thanatephorus cucumeris Dec 1". Biodegradation. 20 (3): 433–440. doi:10.1007/s10532-008-9234-y. PMID 19009358. 
  5. ^ Sugano, Y. (2009). "DyP-type peroxidases comprise a novel heme peroxidase family". Cell. Mol. Life Sci. 66 (8): 1387–1403. doi:10.1007/s00018-008-8651-8. PMID 19099183. 
  6. ^ Ogola, H.J.; Kamiike, T.; Hashimoto, N.; Ashida, H.; Ishikawa, T.; Shibata, H.; Sawa, Y. (2009). "Molecular characterization of a novel peroxidase from the cyanobacterium Anabaena sp. strain PCC 7120". Appl. Environ. Microbiol. 75 (23): 7509–7518. doi:10.1128/AEM.01121-09. PMC 2786418Freely accessible. PMID 19801472. 
  7. ^ van Bloois, E.; Torres Pazmino, D.E.; Winter, R.T.; Fraaije, M.W. (2010). "A robust and extracellular heme-containing peroxidase from Thermobifida fusca as prototype of a bacterial peroxidase superfamily". Appl. Microbiol. Biotechnol. 86 (5): 1419–1430. doi:10.1007/s00253-009-2369-x. PMC 2854361Freely accessible. PMID 19967355. 
  8. ^ Liers, C.; Bobeth, C.; Pecyna, M.; Ullrich, R.; Hofrichter, M. (2010). "DyP-like peroxidases of the jelly fungus Auricularia auricula-judae oxidize nonphenolic lignin model compounds and high-redox potential dyes". Appl. Microbiol. Biotechnol. 85 (6): 1869–1879. doi:10.1007/s00253-009-2173-7. PMID 19756587. 
  9. ^ Hofrichter, M.; Ullrich, R.; Pecyna, M.J.; Liers, C.; Lundell, T. (2010). "New and classic families of secreted fungal heme peroxidases". Appl. Microbiol. Biotechnol. 87 (3): 871–897. doi:10.1007/s00253-010-2633-0. PMID 20495915. 

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