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Classification and external resources
Specialty hematology
ICD-10 D80.2-D80.4
ICD-9-CM 279.06
MeSH D004406

Dysgammaglobulinemia is a type of immune disorder characterized by a reduction in some types of gamma globulins, resulting in heightened susceptibility to some infectious diseases where primary immunity is antibody based.[1][2]

It is distinguished from hypogammaglobulinemia, which is a reduction in all types of gamma globulins.[3]

Hyper IgM syndrome can be considered a form of dysgammaglobulinemia, because it results from a failure of transformation from IgM production to production of other antibodies, and so the condition can be interpreted as a reduction of the other types.

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