E = mc2 is the equation of mass–energy equivalence.
E=MC2 or E=MC2 may also refer to:
- E=MC² (Mariah Carey album), a 2008 album by Mariah Carey
- "E=MC2", a song by Ayreon on the 2008 album 01011001
- "E=MC2" (song), a 1986 song by Big Audio Dynamite
- E=MC² (Giorgio Moroder album), a 1979 album by Giorgio Moroder
- E=MC² (Count Basie album) or The Atomic Mr. Basie, a 1958 album by Count Basie
- E=mc2: A Biography of the World's Most Famous Equation, a 2001 book by David Bodanis
- "E=MC2" (poem), a 1961 poem by Rosser Reeves
- "E=MC2", a 1946 poem by Morris Bishop
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