E-Series may refer to:
- E-Series, a fictional line of robots created by Dr. Ivo "Eggman" Robotnik in the Sonic the Hedgehog series of video games.
- Ford E-Series (Econoline/Club Wagon), a series of vans
- Entwicklung series, a late World War II German standardised tank series
- Nokia Eseries, Nokia business-oriented smartphones
- HP E-series, a series of digital cameras
- BMC E-Series engine, a series of automobile engines
- Honda E engine, a series of automobile engines
- Honda E series, a collection of humanoid robots
- The E-series of preferred numbers
- QI (E series), the fifth series of the TV quiz show QI
- Intel Xeon E series, a line of server-class CPUs.
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