E2F2

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E2F2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesE2F2, E2F-2, E2F transcription factor 2
External IDsMGI: 1096341 HomoloGene: 48264 GeneCards: E2F2
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for E2F2
Genomic location for E2F2
Band1p36.12Start23,506,438 bp[1]
End23,531,233 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004091

NM_177733
NM_183301
NM_001305399

RefSeq (protein)

NP_004082

NP_001292328
NP_808401

Location (UCSC)Chr 1: 23.51 – 23.53 MbChr 4: 136.17 – 136.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[5][6]

Function[edit]

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[7]

Interactions[edit]

E2F2 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b c ENSG00000282899 GRCh38: Ensembl release 89: ENSG00000007968, ENSG00000282899 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018983 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Ivey-Hoyle M, Conroy R, Huber HE, Goodhart PJ, Oliff A, Heimbrook DC (January 1994). "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol. 13 (12): 7802–12. doi:10.1128/MCB.13.12.7802. PMC 364852. PMID 8246995.
  6. ^ Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K (January 1994). "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol. 13 (12): 7813–25. doi:10.1128/mcb.13.12.7813. PMC 364853. PMID 8246996.
  7. ^ "Entrez Gene: E2F2 E2F transcription factor 2".
  8. ^ Crowley TE, Kaine EM, Yoshida M, Nandi A, Wolgemuth DJ (August 2002). "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. doi:10.1210/me.2001-0353. PMID 12145330.
  9. ^ Denis GV, Vaziri C, Guo N, Faller DV (August 2000). "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. PMC 3968681. PMID 10965846.
  10. ^ Schlisio S, Halperin T, Vidal M, Nevins JR (November 2002). "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. doi:10.1093/emboj/cdf577. PMC 131074. PMID 12411495.
  11. ^ Lee C, Chang JH, Lee HS, Cho Y (December 2002). "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. 16 (24): 3199–212. doi:10.1101/gad.1046102. PMC 187509. PMID 12502741.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.