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E4F transcription factor 1
Symbols E4F1 ; E4F
External IDs OMIM603022 MGI109530 HomoloGene3259 GeneCards: E4F1 Gene
RNA expression pattern
PBB GE E4F1 218524 at tn.png
More reference expression data
Species Human Mouse
Entrez 1877 13560
Ensembl ENSG00000167967 ENSMUSG00000024137
UniProt Q66K89 Q8CCE9
RefSeq (mRNA) NM_001288776 NM_001301784
RefSeq (protein) NP_001275705 NP_001288713
Location (UCSC) Chr 16:
2.22 – 2.24 Mb
Chr 17:
24.44 – 24.46 Mb
PubMed search [1] [2]

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[1][2][3]


The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[3]


E4F1 has been shown to interact with:


  1. ^ Saccone S, Sandy P, Meroni G, Gostissa M, Della Valle G, Del Sal G (November 1998). "Assignment of the E1A-regulated transcription factor E4F gene (E4F1) to human chromosome band 16p13.3 by in situ hybridization and somatic cell hybrids". Cytogenet Cell Genet 82 (1-2): 99–100. doi:10.1159/000015075. PMID 9763670. 
  2. ^ Burn TC, Connors TD, Van Raay TJ, Dackowski WR, Millholland JM, Klinger KW, Landes GM (December 1996). "Generation of a transcriptional map for a 700-kb region surrounding the polycystic kidney disease type 1 (PKD1) and tuberous sclerosis type 2 (TSC2) disease genes on human chromosome 16p3.3". Genome Res 6 (6): 525–37. doi:10.1101/gr.6.6.525. PMID 8828041. 
  3. ^ a b "Entrez Gene: E4F1 E4F transcription factor 1". 
  4. ^ a b Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (February 2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–9. doi:10.1074/jbc.M210978200. PMID 12446718. 
  5. ^ Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (January 2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene 19 (2): 188–99. doi:10.1038/sj.onc.1203250. PMID 10644996. 
  6. ^ Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (July 2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–43. doi:10.1073/pnas.130198397. PMC 16614. PMID 10869426. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.