Chlortetracycline

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Chlortetracycline
Chlortetracycline structure.svg
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
By mouth, IV, topical
ATC code
Pharmacokinetic data
Bioavailability30%
Protein binding50 to 55%
MetabolismHepatic (75%)
Elimination half-life5.6 to 9 hours
ExcretionRenal and biliary
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E numberE702 (antibiotics) Edit this at Wikidata
ECHA InfoCard100.000.310 Edit this at Wikidata
Chemical and physical data
FormulaC22H23ClN2O8
Molar mass478.882 g/mol[2]
3D model (JSmol)
Melting point168 to 169 °C (334 to 336 °F)
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Chlortetracycline (trade name Aureomycin, Lederle) is a tetracycline antibiotic, the first tetracycline to be identified. It was discovered in 1945 at Lederle Laboratories under the supervision of Yellapragada Subbarow and his junior Benjamin Minge Duggar. Duggar identified the antibiotic as the product of an actinomycete he cultured from a soil sample collected from Sanborn Field at the University of Missouri.[3] The organism was named Streptomyces aureofaciens and the isolated drug, Aureomycin, because of their golden color.[2]

In veterinary medicine, chlortetracycline is commonly used to treat conjunctivitis in cats.[4]

Chlortetracycline may increase the anticoagulant activities of acenocoumarol. The risk or severity of adverse effects can be increased when chlortetracycline is combined with acitretin, adapalene, or alitretinoin. Aluminum phosphate and aluminum hydroxide can cause decreases in the absorption of chlortetracycline resulting in a reduced serum concentration and potentially a decrease in efficacy. The therapeutic efficacy of mecillinam (amdinocillin), amoxicillin, and ampicillin can be decreased when used in combination with chlortetracycline. Chlortetracycline may increase the neuromuscular blocking activities of atracurium besilate.[5]

References[edit]

  1. ^ "chlortetracycline | C22H23ClN2O8 - PubChem". Pubchem.ncbi.nlm.nih.gov. Retrieved 2017-03-13.
  2. ^ a b "chlortetracycline | C22H23ClN2O8 - PubChem". Pubchem.ncbi.nlm.nih.gov. Retrieved 2017-03-13.
  3. ^ Jukes, Thomas H. Some historical notes on chlortetracycline. Reviews of Infectious Diseases 7(5):702-707 (1985).
  4. ^ Merck Veterinary Manual. Merckvetmanual.com. Retrieved 2017-03-13.
  5. ^ "Chlortetracycline - DrugBank". Drugbank.ca. Retrieved 2017-03-13.