EAL domain

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EAL domain
PDB 2bas EBI.jpg
crystal structure of the bacillus subtilis ykui protein, with an eal domain.

In molecular biology, the EAL domain is a conserved protein domain. It is found in diverse bacterial signalling proteins. It is named EAL after its conserved residues. The EAL domain may function as a diguanylate phosphodiesterase.[1] The domain contains many conserved acidic residues that could participate in metal binding and might form the phosphodiesterase active site.


  1. ^ Galperin MY, Nikolskaya AN, Koonin EV (September 2001). "Novel domains of the prokaryotic two-component signal transduction systems". FEMS Microbiol. Lett. 203 (1): 11–21. doi:10.1016/S0378-1097(01)00326-3. PMID 11557134.
This article incorporates text from the public domain Pfam and InterPro: IPR001633