ECH1

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Enoyl CoA hydratase 1, peroxisomal
2vre.png
Human Peroxisomal Delta3,5, Delta2,4-Dienoyl CoA Isomerase. PDB 2vre
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols ECH1 ; HPXEL
External IDs OMIM600696 MGI1858208 HomoloGene1069 GeneCards: ECH1 Gene
RNA expression pattern
PBB GE ECH1 200789 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1891 51798
Ensembl ENSG00000104823 ENSMUSG00000053898
UniProt Q13011 O35459
RefSeq (mRNA) NM_001398 NM_016772
RefSeq (protein) NP_001389 NP_058052
Location (UCSC) Chr 19:
38.82 – 38.83 Mb
Chr 7:
28.83 – 28.83 Mb
PubMed search [1] [2]

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[1][2][1]

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[2]

References[edit]

  1. ^ a b FitzPatrick DR, Germain-Lee E, Valle D (Nov 1995). "Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase". Genomics 27 (3): 457–66. doi:10.1006/geno.1995.1077. PMID 7558027. 
  2. ^ a b "Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal". 

Further reading[edit]