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Enoyl CoA hydratase 1, peroxisomal
Human Peroxisomal Delta3,5, Delta2,4-Dienoyl CoA Isomerase. PDB 2vre
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ECH1 ; HPXEL
External IDs OMIM600696 MGI1858208 HomoloGene1069 GeneCards: ECH1 Gene
RNA expression pattern
PBB GE ECH1 200789 at tn.png
More reference expression data
Species Human Mouse
Entrez 1891 51798
Ensembl ENSG00000104823 ENSMUSG00000053898
UniProt Q13011 O35459
RefSeq (mRNA) NM_001398 NM_016772
RefSeq (protein) NP_001389 NP_058052
Location (UCSC) Chr 19:
38.82 – 38.83 Mb
Chr 7:
28.83 – 28.83 Mb
PubMed search [1] [2]

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[1][2][1]

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[2]


  1. ^ a b FitzPatrick DR, Germain-Lee E, Valle D (Nov 1995). "Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase". Genomics 27 (3): 457–66. doi:10.1006/geno.1995.1077. PMID 7558027. 
  2. ^ a b "Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal". 

Further reading[edit]