ECH1

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ECH1
2vre.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ECH1, HPXEL, enoyl-CoA hydratase 1, peroxisomal
External IDs MGI: 1858208 HomoloGene: 1069 GeneCards: ECH1
RNA expression pattern
PBB GE ECH1 200789 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001398

NM_016772

RefSeq (protein)

NP_001389

NP_058052.1
NP_058052

Location (UCSC) Chr 19: 38.82 – 38.83 Mb Chr 7: 28.83 – 28.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial is an enzyme that in humans is encoded by the ECH1 gene.[3][3][4]

This gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-CoA hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, Δ3,5-Δ2,4-dienoyl-CoA isomerase, contains a C-terminal peroxisomal targeting sequence and localizes to peroxisomes. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b FitzPatrick DR, Germain-Lee E, Valle D (Nov 1995). "Isolation and characterization of rat and human cDNAs encoding a novel putative peroxisomal enoyl-CoA hydratase". Genomics. 27 (3): 457–66. doi:10.1006/geno.1995.1077. PMID 7558027. 
  4. ^ a b "Entrez Gene: ECH1 enoyl Coenzyme A hydratase 1, peroxisomal". 

Further reading[edit]