ECT2

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ECT2
Protein ECT2 PDB 2cou.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ECT2, ARHGEF31, epithelial cell transforming 2
External IDs MGI: 95281 HomoloGene: 7298 GeneCards: ECT2
Genetically Related Diseases
obesity[1]
RNA expression pattern
PBB GE ECT2 gnf1h01477 at fs.png

PBB GE ECT2 gnf1h08158 at fs.png

PBB GE ECT2 gnf1h01478 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258315
NM_001258316
NM_018098

NM_001177625
NM_001177626
NM_007900

RefSeq (protein)
Location (UCSC) Chr 3: 172.75 – 172.82 Mb Chr 3: 27.1 – 27.15 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Protein ECT2 is a protein that in humans is encoded by the ECT2 gene.[4][5][6]

Function[edit]

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis.[6]

Interactions[edit]

ECT2 has been shown to interact with PARD6A.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with ECT2 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Miki T, Smith CL, Long JE, Eva A, Fleming TP (Apr 1993). "Oncogene ect2 is related to regulators of small GTP-binding proteins". Nature. 362 (6419): 462–5. doi:10.1038/362462a0. PMID 8464478. 
  5. ^ Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T (Dec 1999). "Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis". J. Cell Biol. 147 (5): 921–8. doi:10.1083/jcb.147.5.921. PMC 2169345Freely accessible. PMID 10579713. 
  6. ^ a b "Entrez Gene: ECT2 epithelial cell transforming sequence 2 oncogene". 
  7. ^ Liu XF, Ishida H, Raziuddin R, Miki T (Aug 2004). "Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity". Mol. Cell. Biol. 24 (15): 6665–75. doi:10.1128/MCB.24.15.6665-6675.2004. PMC 444862Freely accessible. PMID 15254234. 

Further reading[edit]