Dichlorochromopyrrolate synthase

From Wikipedia, the free encyclopedia
(Redirected from EC 1.21.3.9)
Dichlorochromopyrrolate synthase
Identifiers
EC no.1.21.3.9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Dichlorochromopyrrolate synthase (EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3-(7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming).[1][2] This enzyme catalyses the following chemical reaction

4 2-imino-3-(7-chloroindol-3-yl)propanoate + O2 2 dichlorochromopyrrolate + 2 NH3 + 2 H2O

This enzyme catalyses a step in the biosynthesis of rebeccamycin.

References[edit]

  1. ^ Nishizawa T, Grüschow S, Jayamaha DH, Nishizawa-Harada C, Sherman DH (January 2006). "Enzymatic assembly of the bis-indole core of rebeccamycin". Journal of the American Chemical Society. 128 (3): 724–5. doi:10.1021/ja056749x. PMID 16417354.
  2. ^ Howard-Jones AR, Walsh CT (December 2005). "Enzymatic generation of the chromopyrrolic acid scaffold of rebeccamycin by the tandem action of RebO and RebD". Biochemistry. 44 (48): 15652–63. CiteSeerX 10.1.1.537.5773. doi:10.1021/bi051706e. PMID 16313168.

External links[edit]