2-hydroxy-3-oxoadipate synthase

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2-hydroxy-3-oxoadipate synthase
EC number
CAS number 9054-72-2
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 2-hydroxy-3-oxoadipate synthase (EC is an enzyme that catalyzes the following chemical reaction:

2-oxoglutarate + glyoxylate 2-hydroxy-3-oxoadipate + CO2

The two substrates of this enzyme are 2-oxoglutarate and glyoxylate, whereas its two products are 2-hydroxy-3-oxoadipate and CO2.

This enzyme belongs to the family of transferases, specifically those transferring aldehyde or ketonic groups (transaldolases and transketolases, respectively). Other names in common use include 2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating), alpha-ketoglutaric-glyoxylic carboligase, and oxoglutarate: glyoxylate carboligase. This enzyme participates in glyoxylate and dicarboxylate metabolism. It employs one cofactor, thiamin diphosphate.


  • Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW (1970). "Carboligase activity of alpha-ketoglutarate dehydrogenase". Biochemistry. 9 (5): 1148–53. doi:10.1021/bi00807a015. PMID 5418712. 
  • Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW (1968). "Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase". Biochemistry. 7 (1): 333–7. doi:10.1021/bi00841a042. PMID 4320439. 
  • Stewart PR, Quayle JR (1967). "The synergistic decarboxylation of glyoxalate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria". Biochem. J. 102: 885–897.