Glycosylphosphatidylinositol phospholipase D

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Glycosylphosphatidylinositol phospholipase D
Identifiers
EC number 3.1.4.50
CAS number 113756-14-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.[1][2][3][4] This enzyme catalyses the following chemical reaction

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O 6-(alpha-D-glucosaminyl)-1D-myo-inositol + 3-sn-phosphatidate

This enzyme cleaves proteins from the lipid part of the glycosylphosphatidylinositol (GPI) anchors.

See also[edit]

References[edit]

  1. ^ Low, M.G.; Prasad, A.R.S. (1988). "A phospholipase D specific for the phosphatidylinositol anchor of cell-surface proteins is abundant in plasma". Proc. Natl. Acad. Sci. USA. 85 (4): 980–984. Bibcode:1988PNAS...85..980L. PMC 279684Freely accessible. PMID 3422494. doi:10.1073/pnas.85.4.980. 
  2. ^ Malik, A.S.; Low, M.G. (1986). "Conversion of human placental alkaline phosphatase from a high Mr form to a low Mr form during butanol extraction. An investigation of the role of endogenous phosphoinositide-specific phospholipases". Biochem. J. 240 (2): 519–527. PMC 1147446Freely accessible. PMID 3028377. 
  3. ^ Li, J.Y.; Hollfelder, K.; Huang, K.S.; Low, M.G. (1994). "Structural features of GPI-specific phospholipase D revealed by fragmentation and Ca2+ binding studies". J. Biol. Chem. 269 (46): 28963–28971. PMID 7961859. 
  4. ^ Deeg, M.A; Vierman, E.L.; Cheung, M.C. (2001). "GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex". J. Lipid Res. 42 (3): 442–451. PMID 11254757. 

External links[edit]