Endothelin 1

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Endothelin 1
PDB 1edn EBI.jpg
Rendering of 1EDN
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EDN1 ; ARCND3; ET1; HDLCQ7; PPET1; QME
External IDs OMIM131240 MGI95283 HomoloGene1476 GeneCards: EDN1 Gene
RNA expression pattern
PBB GE EDN1 218995 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1906 13614
Ensembl ENSG00000078401 ENSMUSG00000021367
UniProt P05305 P22387
RefSeq (mRNA) NM_001168319 NM_010104
RefSeq (protein) NP_001161791 NP_034234
Location (UCSC) Chr 6:
12.29 – 12.3 Mb
Chr 13:
42.3 – 42.31 Mb
PubMed search [1] [2]

Endothelin 1, also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin (ET-1).

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[1]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.


  1. ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4. 

Further reading[edit]

  • Bruno CM, Neri S, Di Prima P, Sciacca C (2003). "Pathophysiology of endothelin and medical emergencies.". Panminerva medica 45 (2): 151–4. PMID 12855940. 
  • Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction.". Expert Opin. Ther. Targets 8 (3): 191–201. doi:10.1517/14728222.8.3.191. PMID 15161426. 
  • Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease.". Pediatr. Res. 57 (5 Pt 2): 16R–20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID 15817494. 
  • Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris) 22 (4): 416–22. doi:10.1051/medsci/2006224416. PMID 16597412. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.