Endothelin 1

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EDN1
PDB 1edn EBI.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EDN1, ARCND3, ET1, HDLCQ7, PPET1, QME, endothelin 1
External IDs MGI: 95283 HomoloGene: 1476 GeneCards: 1906
RNA expression pattern
PBB GE EDN1 218995 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001168319
NM_001955

NM_010104

RefSeq (protein)

NP_001161791.1
NP_001946.3

NP_034234.1

Location (UCSC) Chr 6: 12.29 – 12.3 Mb Chr 13: 42.3 – 42.31 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a protein that in humans is encoded by the EDN1 gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 is one of three isoforms of human endothelin.

Preproendothelin is precursor of the peptide ET-1. Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.[1]

Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.

References[edit]

  1. ^ Boulpaep EL, Boron WF (2009). Medical physiology: a cellular and molecular approach. Saunders/Elsevier. ISBN 1-4160-3115-4. 

Further reading[edit]

  • Bruno CM, Neri S, Di Prima P, Sciacca C (2003). "Pathophysiology of endothelin and medical emergencies.". Panminerva medica 45 (2): 151–4. PMID 12855940. 
  • Doggrell SA (2006). "The endothelin system and its role in acute myocardial infarction.". Expert Opin. Ther. Targets 8 (3): 191–201. doi:10.1517/14728222.8.3.191. PMID 15161426. 
  • Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease.". Pediatr. Res. 57 (5 Pt 2): 16R–20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID 15817494. 
  • Cazaubon S, Deshayes F, Couraud PO, Nahmias C (2006). "[Endothelin-1, angiotensin II and cancer]". Med Sci (Paris) 22 (4): 416–22. doi:10.1051/medsci/2006224416. PMID 16597412. 
  • Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48–56. PMID 17569300. 
  • Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin". Pharmacological Reviews 68 (2): 357–418. doi:10.1124/pr.115.011833. PMID 26956245. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.