Endothelin 2

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Aliases EDN2, ET2, PPET2, ET-2, endothelin 2
External IDs MGI: 95284 HomoloGene: 1477 GeneCards: EDN2
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 41.48 – 41.48 Mb Chr 4: 120.16 – 120.17 Mb
PubMed search [1] [2]
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Endothelin 2, also known as ET-2, is a protein that in humans is encoded by the EDN2 gene.[3]


Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.[3]

Endothelin 2 (ET-2) expression is mainly localized to the granulosa cells within the follicle, as observed in bovine, murine, and human ovarian tissue. Endothelin 2 has functions within the ovarian follicle related to ovulation. ET-2 causes strong contractions in smooth muscle cells of ovarian tissue, and ET-2 production is highest just before ovulation. [4] [5] [6] [7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: endothelin 2". 
  4. ^ Klipper, E., A. Levit, Y. Mastich, B. Berisha, D. Schams, and R. Meidan. 2010. Induction of Endothelin-2 Expression by Luteinizing Hormone and Hypoxia: Possible Role in Bovine Corpus Luteum Formation. Endocrinology. 151:1914–1922.
  5. ^ Ko, C., M.C. Gieske, L. Al-Alem, Y. Hahn, W. Su, M.C. Gong, M. Iglarz, and Y. Koo. 2006. Endothelin-2 in Ovarian Follicular Rupture. Endocrinology. 147:1770–1779.
  6. ^ Na, G., P.J. Bridges, Y. Koo, C. Ko. 2008. Role of hypoxia in the regulation of periovulatory EDN2 expression in the mouse. Canadian Journal of Physiology and Pharmacology. 86:310-319.
  7. ^ Imbar, T., E. Klipper, C. Greenfield, A. Hurwitz, R. Haimov-Kochman, R. Meidan. 2012. Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome. Life Sciences. 91:703–709.

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