Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the vacuole. Mycobacterium tuberculosis is known to inhibit the recruitment of EEA1 to the phagosomal membrane through CamKII.Legionella pneumophila also prevents EEA1 recruitment through a currently unknown mechanism. Interestingly, the related pathogen Legionella longbeachae recruits EEA1 and appears to replicate within a modified early endosome.
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^Urwyler S, Nyfeler Y, Ragaz C, Lee H, Mueller LN, Aebersold R, Hilbi H (Jan 2009). "Proteome analysis of Legionella vacuoles purified by magnetic immunoseparation reveals secretory and endosomal GTPases". Traffic. 10 (1): 76–87. doi:10.1111/j.1600-0854.2008.00851.x. PMID18980612.
^Asare R, Abu Kwaik Y (Jun 2007). "Early trafficking and intracellular replication of Legionella longbeachaea within an ER-derived late endosome-like phagosome". Cellular Microbiology. 9 (6): 1571–87. doi:10.1111/j.1462-5822.2007.00894.x. PMID17309675.