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Eukaryotic translation elongation factor 1 beta 2
Protein EEF1B2 PDB 1b64.png
PDB rendering based on 1b64.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EEF1B2 ; EEF1B; EEF1B1; EF1B
External IDs OMIM600655 MGI1929520 HomoloGene1480 GeneCards: EEF1B2 Gene
Species Human Mouse
Entrez 1933 55949
Ensembl ENSG00000114942 ENSMUSG00000025967
UniProt P24534 O70251
RefSeq (mRNA) NM_001037663 NM_018796
RefSeq (protein) NP_001032752 NP_061266
Location (UCSC) Chr 2:
206.16 – 206.16 Mb
Chr 1:
63.18 – 63.18 Mb
PubMed search [1] [2]

Elongation factor 1-beta is a protein that in humans is encoded by the EEF1B2 gene.[1][2]


This gene encodes a translation elongation factor. The protein is a guanine nucleotide exchange factor involved in the transfer of aminoacylated tRNAs to the ribosome. Alternative splicing results in three transcript variants which differ only in the 5' UTR.[2]


EEF1B2 has been shown to interact with EEF1G[3][4] and HARS.[5]


  1. ^ Pizzuti A, Gennarelli M, Novelli G, Colosimo A, Lo Cicero S, Caskey CT, Dallapiccola B (Nov 1993). "Human elongation factor EF-1 beta: cloning and characterization of the EF1 beta 5a gene and assignment of EF-1 beta isoforms to chromosomes 2,5,15 and X". Biochemical and Biophysical Research Communications 197 (1): 154–62. doi:10.1006/bbrc.1993.2454. PMID 8250921. 
  2. ^ a b "Entrez Gene: EEF1B2 eukaryotic translation elongation factor 1 beta 2". 
  3. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  4. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  5. ^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 

Further reading[edit]

  • Rasmussen HH, van Damme J, Puype M, Gesser B, Celis JE, Vandekerckhove J (Dec 1992). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667. 
  • Hochstrasser DF, Frutiger S, Paquet N, Bairoch A, Ravier F, Pasquali C, Sanchez JC, Tissot JD, Bjellqvist B, Vargas R (Dec 1992). "Human liver protein map: a reference database established by microsequencing and gel comparison". Electrophoresis 13 (12): 992–1001. doi:10.1002/elps.11501301201. PMID 1286669. 
  • von der Kammer H, Klaudiny J, Zimmer M, Scheit KH (May 1991). "Human elongation factor 1 beta: cDNA and derived amino acid sequence". Biochemical and Biophysical Research Communications 177 (1): 312–7. doi:10.1016/0006-291X(91)91984-K. PMID 1710449. 
  • Sanders J, Maassen JA, Amons R, Möller W (Aug 1991). "Nucleotide sequence of human elongation factor-1 beta cDNA". Nucleic Acids Research 19 (16): 4551. doi:10.1093/nar/19.16.4551. PMC 328648. PMID 1886777. 
  • Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry 264 (35): 21131–7. PMID 2556394. 
  • Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. 
  • Chen CJ, Traugh JA (Dec 1995). "Expression of recombinant elongation factor 1 beta from rabbit in Escherichia coli. Phosphorylation by casein kinase II". Biochimica Et Biophysica Acta 1264 (3): 303–11. doi:10.1016/0167-4781(95)00166-2. PMID 8547318. 
  • Béhar G, Coleclough C, Houlgatte R, Auffray C, Lefkovits I (1996). "Human lymphocyte cDNA ordered library analyzed by 2D gel electrophoresis. 3. Analysis of individual clones". Applied and Theoretical Electrophoresis 5 (2): 99–105. PMID 8573604. 
  • Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science. 109 ( Pt 5) (5): 1113–7. PMID 8743958. 
  • Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID 9407120. 
  • Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry 191 (1-2): 181–6. doi:10.1023/A:1006802125856. PMID 10094407. 
  • Pérez JM, Siegal G, Kriek J, Hård K, Dijk J, Canters GW, Möller W (Feb 1999). "The solution structure of the guanine nucleotide exchange domain of human elongation factor 1beta reveals a striking resemblance to that of EF-Ts from Escherichia coli". Structure 7 (2): 217–26. doi:10.1016/S0969-2126(99)80027-6. PMID 10368288. 
  • Chambers DM, Rouleau GA, Abbott CM (Oct 2001). "Comparative genomic analysis of genes encoding translation elongation factor 1B(alpha) in human and mouse shows EEF1B1 to be a recent retrotransposition event". Genomics 77 (3): 145–8. doi:10.1006/geno.2001.6626. PMID 11597139. 
  • Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 
  • Cans C, Passer BJ, Shalak V, Nancy-Portebois V, Crible V, Amzallag N, Allanic D, Tufino R, Argentini M, Moras D, Fiucci G, Goud B, Mirande M, Amson R, Telerman A (Nov 2003). "Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A". Proceedings of the National Academy of Sciences of the United States of America 100 (24): 13892–7. doi:10.1073/pnas.2335950100. PMC 283517. PMID 14623968. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. 
  • Ito T, Marintchev A, Wagner G (Sep 2004). "Solution structure of human initiation factor eIF2alpha reveals homology to the elongation factor eEF1B". Structure 12 (9): 1693–704. doi:10.1016/j.str.2004.07.010. PMID 15341733.