EEF1D

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Eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols EEF1D ; EF-1D; EF1D; FP1047
External IDs OMIM130592 MGI1913906 HomoloGene23404 GeneCards: EEF1D Gene
RNA expression pattern
PBB GE EEF1D 203113 s at tn.png
PBB GE EEF1D 214394 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1936 66656
Ensembl ENSG00000104529 ENSMUSG00000055762
UniProt P29692 P57776
RefSeq (mRNA) NM_001130053 NM_001285429
RefSeq (protein) NP_001123525 NP_001272358
Location (UCSC) Chr 8:
143.58 – 143.6 Mb
Chr 15:
75.89 – 75.91 Mb
PubMed search [1] [2]

Elongation factor 1-delta is a protein that in humans is encoded by the EEF1D gene.[1]

Function[edit]

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit functions as guanine nucleotide exchange factor. It is reported that this subunit interacts with HIV-1 Tat, and thus it represses the translation of host-cell, but not HIV-1, mRNAs. Several alternatively spliced transcript variants have been found for this gene, however, the full length nature of only two variants has been determined.[2]

Interactions[edit]

EEF1D has been shown to interact with Glycyl-tRNA synthetase,[3] EEF1G[4][5] and KTN1,[6] and is predicted to interact with TMEM63A.[7]

References[edit]

  1. ^ Sanders J, Raggiaschi R, Morales J, Möller W (Jul 1993). "The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1 delta". Biochimica Et Biophysica Acta 1174 (1): 87–90. doi:10.1016/0167-4781(93)90097-W. PMID 8334168. 
  2. ^ "Entrez Gene: EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)". 
  3. ^ Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  6. ^ Ong LL, Er CP, Ho A, Aung MT, Yu H (Aug 2003). "Kinectin anchors the translation elongation factor-1 delta to the endoplasmic reticulum". The Journal of Biological Chemistry 278 (34): 32115–23. doi:10.1074/jbc.M210917200. PMID 12773547. 
  7. ^ "String Database". Retrieved 16 May 2014. 

Further reading[edit]

  • Venema RC, Peters HI, Traugh JA (Jul 1991). "Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity". The Journal of Biological Chemistry 266 (19): 12574–80. PMID 2061327. 
  • van Damme HT, Amons R, Karssies R, Timmers CJ, Janssen GM, Möller W (Aug 1990). "Elongation factor 1 beta of artemia: localization of functional sites and homology to elongation factor 1 delta". Biochimica Et Biophysica Acta 1050 (1-3): 241–7. doi:10.1016/0167-4781(90)90174-z. PMID 2207149. 
  • Bec G, Kerjan P, Zha XD, Waller JP (Dec 1989). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1". The Journal of Biological Chemistry 264 (35): 21131–7. PMID 2556394. 
  • Wolfson AD, Orlovsky AF, Gladilin KL (Oct 1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor". FEBS Letters 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261. 
  • Mulner-Lorillon O, Minella O, Cormier P, Capony JP, Cavadore JC, Morales J, Poulhe R, Bellé R (Aug 1994). "Elongation factor EF-1 delta, a new target for maturation-promoting factor in Xenopus oocytes". The Journal of Biological Chemistry 269 (31): 20201–7. PMID 8051108. 
  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
  • Bec G, Kerjan P, Waller JP (Jan 1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation". The Journal of Biological Chemistry 269 (3): 2086–92. PMID 8294461. 
  • Sanders J, Brandsma M, Janssen GM, Dijk J, Möller W (May 1996). "Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum". Journal of Cell Science 109 (5): 1113–7. PMID 8743958. 
  • Chang YW, Traugh JA (Nov 1997). "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry 272 (45): 28252–7. doi:10.1074/jbc.272.45.28252. PMID 9353277. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
  • Sheu GT, Traugh JA (Dec 1997). "Recombinant subunits of mammalian elongation factor 1 expressed in Escherichia coli. Subunit interactions, elongation activity, and phosphorylation by protein kinase CKII". The Journal of Biological Chemistry 272 (52): 33290–7. doi:10.1074/jbc.272.52.33290. PMID 9407120. 
  • Xiao H, Neuveut C, Benkirane M, Jeang KT (Mar 1998). "Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation". Biochemical and Biophysical Research Communications 244 (2): 384–9. doi:10.1006/bbrc.1998.8274. PMID 9514931. 
  • Kolettas E, Lymboura M, Khazaie K, Luqmani Y (1998). "Modulation of elongation factor-1 delta (EF-1 delta) expression by oncogenes in human epithelial cells". Anticancer Research 18 (1A): 385–92. PMID 9568107. 
  • Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". International Journal of Cancer. Journal International Du Cancer 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721. 
  • Chacko G, Ling Q, Hajjar KA (Jul 1998). "Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta". The Journal of Biological Chemistry 273 (31): 19840–6. doi:10.1074/jbc.273.31.19840. PMID 9677419. 
  • Sheu GT, Traugh JA (Jan 1999). "A structural model for elongation factor 1 (EF-1) and phosphorylation by protein kinase CKII". Molecular and Cellular Biochemistry 191 (1-2): 181–6. doi:10.1023/A:1006802125856. PMID 10094407. 
  • Furusawa T, Moribe H, Kondoh H, Higashi Y (Dec 1999). "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1". Molecular and Cellular Biology 19 (12): 8581–90. doi:10.1128/mcb.19.12.8581. PMC 84984. PMID 10567582. 
  • Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (Feb 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochemical and Biophysical Research Communications 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 
  • Lei YX, Chen JK, Wu ZL (2002). "Blocking the translation elongation factor-1 delta with its antisense mRNA results in a significant reversal of its oncogenic potential". Teratogenesis, Carcinogenesis, and Mutagenesis 22 (5): 377–83. doi:10.1002/tcm.10034. PMID 12210501.