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Eukaryotic translation elongation factor 1 gamma
Protein EEF1G PDB 1pbu.png
PDB rendering based on 1pbu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EEF1G ; EF1G; GIG35
External IDs OMIM130593 MGI1914410 HomoloGene20363 GeneCards: EEF1G Gene
Species Human Mouse
Entrez 1937 67160
Ensembl ENSG00000254772 ENSMUSG00000071644
UniProt P26641 Q9D8N0
RefSeq (mRNA) NM_001404 NM_026007
RefSeq (protein) NP_001395 NP_080283
Location (UCSC) Chr 11:
62.33 – 62.34 Mb
Chr 19:
8.97 – 8.98 Mb
PubMed search [1] [2]

Elongation factor 1-gamma is a protein that in humans is encoded by the EEF1G gene.[1][2][3]


This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases.[3]


EEF1G has been shown to interact with:


  1. ^ Kumabe T, Sohma Y, Yamamoto T (July 1992). "Human cDNAs encoding elongation factor 1 gamma and the ribosomal protein L19". Nucleic Acids Res 20 (10): 2598. doi:10.1093/nar/20.10.2598. PMC 312399. PMID 1598220. 
  2. ^ Sanders J, Maassen JA, Möller W (January 1993). "Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation". Nucleic Acids Res 20 (22): 5907–10. doi:10.1093/nar/20.22.5907. PMC 334453. PMID 1461723. 
  3. ^ a b "Entrez Gene: EEF1G eukaryotic translation elongation factor 1 gamma". 
  4. ^ a b c Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H et al. (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  5. ^ a b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ a b Sang Lee J, Gyu Park S, Park H, Seol W, Lee S, Kim S (February 2002). "Interaction network of human aminoacyl-tRNA synthetases and subunits of elongation factor 1 complex". Biochem. Biophys. Res. Commun. 291 (1): 158–64. doi:10.1006/bbrc.2002.6398. PMID 11829477. 
  7. ^ Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F et al. (August 2001). "FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis". Proc. Natl. Acad. Sci. U.S.A. 98 (18): 10374–9. doi:10.1073/pnas.181222898. PMC 56968. PMID 11504921. 

Further reading[edit]