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Eukaryotic translation elongation factor 2
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EEF2 ; EEF-2; EF-2; EF2; SCA26
External IDs OMIM130610 MGI95288 HomoloGene134867 ChEMBL: 1795108 GeneCards: EEF2 Gene
RNA expression pattern
PBB GE EEF2 204102 s at tn.png
PBB GE EEF2 200094 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1938 13629
Ensembl ENSG00000167658 ENSMUSG00000034994
UniProt P13639 P58252
RefSeq (mRNA) NM_001961 NM_007907
RefSeq (protein) NP_001952 NP_031933
Location (UCSC) Chr 19:
3.98 – 3.99 Mb
Chr 10:
81.18 – 81.18 Mb
PubMed search [1] [2]

Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene.[1][2][3]

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the ribosome. This protein is completely inactivated by EF-2 kinase phosphorylation.[3]

It is the target of diphtheria toxin and exotoxin A.[4]


  1. ^ Rapp G, Klaudiny J, Hagendorff G, Luck MR, Scheit KH (Mar 1990). "Complete sequence of the coding region of human elongation factor 2 (EF-2) by enzymatic amplification of cDNA from human ovarian granulosa cells". Biol Chem Hoppe Seyler 370 (10): 1071–5. doi:10.1515/bchm3.1989.370.2.1071. PMID 2610926. 
  2. ^ Kaneda Y, Yoshida MC, Kohno K, Uchida T, Okada Y (Jul 1984). "Chromosomal assignment of the gene for human elongation factor 2". Proc Natl Acad Sci U S A 81 (10): 3158–62. doi:10.1073/pnas.81.10.3158. PMC 345240. PMID 6427766. 
  3. ^ a b "Entrez Gene: EEF2 eukaryotic translation elongation factor 2". 
  4. ^ Jørgensen R, Merrill AR, Andersen GR (February 2006). "The life and death of translation elongation factor 2". Biochem. Soc. Trans. 34 (Pt 1): 1–6. doi:10.1042/BST20060001. PMID 16246167. 

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