Delta8-fatty-acid desaturase

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Delta8-fatty-acid desaturase
Identifiers
EC number 1.14.19.4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Delta8-fatty-acid desaturase (EC 1.14.19.4, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an enzyme with systematic name phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

phytosphinganine + reduced acceptor + O2 Delta8-phytosphingenine + acceptor + 2 H2O

This enzyme, which has been found mainly in plants, introduces a double bond at Delta8 of C18 and C20 fatty acids.

References[edit]

  1. ^ Wallis, J.G.; Browse, J. (1999). "The Δ8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids". Arch. Biochem. Biophys. 365: 307–316. doi:10.1006/abbi.1999.1167. PMID 10328826. 
  2. ^ Sperling, P.; Libisch, B.; Zähringer, U.; Napier, J.A.; Heinz, E. (2001). "Functional identification of a Δ8-sphingolipid desaturase from Borago officinalis". Arch. Biochem. Biophys. 388: 293–298. doi:10.1006/abbi.2001.2308. PMID 11368168. 
  3. ^ Takakuwa, N.; Kinoshita, M.; Oda, Y.; Ohnishi, M. (2002). "Isolation and characterization of the genes encoding Δ8-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis'". Curr. Microbiol. 45: 459–461. doi:10.1007/s00284-002-3860-0. PMID 12402089. 
  4. ^ Beckmann, C.; Rattke, J.; Oldham, N.J.; Sperling, P.; Heinz, E.; Boland, W. (2002). "Characterization of a Δ8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers". Angew. Chem. Int. Ed. Engl. 41: 2298–2300. doi:10.1002/1521-3773(20020703)41:13<2298::AID-ANIE2298>3.0.CO;2-G. PMID 12203571. 

External links[edit]