Delta8-fatty-acid desaturase

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Delta8-fatty-acid desaturase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Delta8-fatty-acid desaturase (EC, Delta8-sphingolipid desaturase, EFD1, BoDES8, SLD, Delta8 fatty acid desaturase, Delta8-desaturase) is an enzyme with systematic name phytosphinganine,hydrogen donor:oxygen Delta8-oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction

phytosphinganine + reduced acceptor + O2 Delta8-phytosphingenine + acceptor + 2 H2O

This enzyme, which has been found mainly in plants, introduces a double bond at Delta8 of C18 and C20 fatty acids.


  1. ^ Wallis, J.G.; Browse, J. (1999). "The Δ8-desaturase of Euglena gracilis: an alternate pathway for synthesis of 20-carbon polyunsaturated fatty acids". Arch. Biochem. Biophys. 365: 307–316. doi:10.1006/abbi.1999.1167. PMID 10328826. 
  2. ^ Sperling, P.; Libisch, B.; Zähringer, U.; Napier, J.A.; Heinz, E. (2001). "Functional identification of a Δ8-sphingolipid desaturase from Borago officinalis". Arch. Biochem. Biophys. 388: 293–298. doi:10.1006/abbi.2001.2308. PMID 11368168. 
  3. ^ Takakuwa, N.; Kinoshita, M.; Oda, Y.; Ohnishi, M. (2002). "Isolation and characterization of the genes encoding Δ8-sphingolipid desaturase from Saccharomyces kluyveri and Kluyveromyces lactis'". Curr. Microbiol. 45: 459–461. doi:10.1007/s00284-002-3860-0. PMID 12402089. 
  4. ^ Beckmann, C.; Rattke, J.; Oldham, N.J.; Sperling, P.; Heinz, E.; Boland, W. (2002). "Characterization of a Δ8-sphingolipid desaturase from higher plants: a stereochemical and mechanistic study on the origin of E,Z isomers". Angew. Chem. Int. Ed. Engl. 41: 2298–2300. doi:10.1002/1521-3773(20020703)41:13<2298::AID-ANIE2298>3.0.CO;2-G. PMID 12203571. 

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