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Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EFNA2 ; ELF-1; EPLG6; HEK7-L; LERK-6; LERK6
External IDs OMIM602756 MGI102707 HomoloGene1075 ChEMBL: 1795109 GeneCards: EFNA2 Gene
RNA expression pattern
PBB GE EFNA2 208256 at tn.png
More reference expression data
Species Human Mouse
Entrez 1943 13637
Ensembl ENSG00000099617 ENSMUSG00000003070
UniProt O43921 P52801
RefSeq (mRNA) NM_001405 NM_007909
RefSeq (protein) NP_001396 NP_031935
Location (UCSC) Chr 19:
1.29 – 1.3 Mb
Chr 10:
80.18 – 80.19 Mb
PubMed search [1] [2]

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.[1]

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[1]


Further reading[edit]