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Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EFNA2 ; ELF-1; EPLG6; HEK7-L; LERK-6; LERK6
External IDs OMIM602756 MGI102707 HomoloGene1075 ChEMBL: 1795109 GeneCards: EFNA2 Gene
RNA expression pattern
PBB GE EFNA2 208256 at tn.png
More reference expression data
Species Human Mouse
Entrez 1943 13637
Ensembl ENSG00000099617 ENSMUSG00000003070
UniProt O43921 P52801
RefSeq (mRNA) NM_001405 NM_007909
RefSeq (protein) NP_001396 NP_031935
Location (UCSC) Chr 19:
1.29 – 1.3 Mb
Chr 10:
80.18 – 80.19 Mb
PubMed search [1] [2]

Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene.[1]

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.[1]


Further reading[edit]

  • Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID 9530499. 
  • Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID 9576626. 
  • Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development 126 (10): 2033–44. PMID 10207129. 
  • Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN 978-0-12-364600-2. PMID 10730216. 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993. 
  • Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID 11256076. 
  • Gale NW; Holland SJ; Valenzuela DM et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474. 
  • Ephnomenclaturecommittee, (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020. 
  • Cerretti DP, Nelson N (1998). "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure". Genomics 47 (1): 131–5. doi:10.1006/geno.1997.5088. PMID 9465306. 
  • Ciossek T; Monschau B; Kremoser C et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci. 10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID 9751130. 
  • Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T (1998). "Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2". Biochem. Biophys. Res. Commun. 252 (2): 378–82. doi:10.1006/bbrc.1998.9618. PMID 9826538. 
  • Gerlai R; Shinsky N; Shih A et al. (1999). "Regulation of learning by EphA receptors: a protein targeting study". J. Neurosci. 19 (21): 9538–49. PMID 10531456. 
  • Hattori M, Osterfield M, Flanagan JG (2000). "Regulated cleavage of a contact-mediated axon repellent". Science 289 (5483): 1360–5. doi:10.1126/science.289.5483.1360. PMID 10958785. 
  • Rodger J; Lindsey KA; Leaver SG et al. (2002). "Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat". Eur. J. Neurosci. 14 (12): 1929–36. doi:10.1046/j.0953-816x.2001.01822.x. PMID 11860487.