This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci.2 (3): 155–64. doi:10.1038/35058515. PMID11256076.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID8755474.
Cerretti DP, Nelson N (1998). "Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 (EPLG6): conservation of intron/exon structure". Genomics47 (1): 131–5. doi:10.1006/geno.1997.5088. PMID9465306.
Ciossek T, Monschau B, Kremoser C, et al. (1998). "Eph receptor-ligand interactions are necessary for guidance of retinal ganglion cell axons in vitro". Eur. J. Neurosci.10 (5): 1574–80. doi:10.1046/j.1460-9568.1998.00180.x. PMID9751130.
Aasheim HC, Pedeutour F, Grosgeorge J, Logtenberg T (1998). "Cloning, chromosal mapping, and tissue expression of the gene encoding the human Eph-family kinase ligand ephrin-A2". Biochem. Biophys. Res. Commun.252 (2): 378–82. doi:10.1006/bbrc.1998.9618. PMID9826538.
Gerlai R, Shinsky N, Shih A, et al. (1999). "Regulation of learning by EphA receptors: a protein targeting study". J. Neurosci.19 (21): 9538–49. PMID10531456.
Rodger J, Lindsey KA, Leaver SG, et al. (2002). "Expression of ephrin-A2 in the superior colliculus and EphA5 in the retina following optic nerve section in adult rat". Eur. J. Neurosci.14 (12): 1929–36. doi:10.1046/j.0953-816x.2001.01822.x. PMID11860487.