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Protein EFNB2 PDB 1iko.png
PDB rendering based on 1iko.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EFNB2 ; EPLG5; HTKL; Htk-L; LERK5
External IDs OMIM600527 MGI105097 HomoloGene3019 GeneCards: EFNB2 Gene
RNA expression pattern
PBB GE EFNB2 202668 at tn.png
PBB GE EFNB2 202669 s at tn.png
More reference expression data
Species Human Mouse
Entrez 1948 13642
Ensembl ENSG00000125266 ENSMUSG00000001300
UniProt P52799 P52800
RefSeq (mRNA) NM_004093 NM_010111
RefSeq (protein) NP_004084 NP_034241
Location (UCSC) Chr 13:
106.49 – 106.54 Mb
Chr 8:
8.62 – 8.66 Mb
PubMed search [1] [2]

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.[1]

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.[2]


EFNB2 has been shown to interact with EPHA3.[3][4]


  1. ^ Bonaldo MF, Yu MT, Jelenc P, Brown S, Su L, Lawton L, Deaven L, Efstratiadis A, Warburton D, Soares MB (February 1995). "Selection of cDNAs using chromosome-specific genomic clones: application to human chromosome 13". Hum Mol Genet 3 (9): 1663–73. doi:10.1093/hmg/3.9.1663. PMID 7833926. 
  2. ^ "Entrez Gene: EFNB2 ephrin-B2". 
  3. ^ Cerretti, D P; Vanden Bos T; Nelson N; Kozlosky C J; Reddy P; Maraskovsky E; Park L S; Lyman S D; Copeland N G; Gilbert D J (November 1995). "Isolation of LERK-5: a ligand of the eph-related receptor tyrosine kinases". Mol. Immunol. (ENGLAND) 32 (16): 1197–205. doi:10.1016/0161-5890(95)00108-5. ISSN 0161-5890. PMID 8559144. 
  4. ^ Lackmann, M; Mann R J, Kravets L, Smith F M, Bucci T A, Maxwell K F, Howlett G J, Olsson J E, Vanden Bos T, Cerretti D P, Boyd A W (June 1997). "Ligand for EPH-related kinase (LERK) 7 is the preferred high affinity ligand for the HEK receptor". J. Biol. Chem. (UNITED STATES) 272 (26): 16521–30. doi:10.1074/jbc.272.26.16521. ISSN 0021-9258. PMID 9195962. 

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