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Egl-9 family hypoxia-inducible factor 2
Symbols EGLN2 ; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1
External IDs OMIM606424 MGI1932287 HomoloGene14204 ChEMBL: 3028 GeneCards: EGLN2 Gene
EC number
RNA expression pattern
PBB GE EGLN2 220956 s at tn.png
More reference expression data
Species Human Mouse
Entrez 112398 112406
Ensembl ENSG00000269858 ENSMUSG00000058709
UniProt Q96KS0 Q91YE2
RefSeq (mRNA) NM_017555 NM_053208
RefSeq (protein) NP_444274 NP_444438
Location (UCSC) Chr 19:
40.8 – 40.81 Mb
Chr 7:
27.16 – 27.17 Mb
PubMed search [1] [2]

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.[1]

The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation.

This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[1]


Further reading[edit]