EGLN2

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EGLN2
Identifiers
Aliases EGLN2, EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1, egl-9 family hypoxia inducible factor 2
External IDs MGI: 1932287 HomoloGene: 14204 GeneCards: EGLN2
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for EGLN2
Genomic location for EGLN2
Band 19q13.2 Start 40,798,996 bp[1]
End 40,808,433 bp[1]
RNA expression pattern
PBB GE EGLN2 220956 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080732
NM_017555
NM_053046

NM_053208

RefSeq (protein)

NP_444274
NP_542770

NP_444438

Location (UCSC) Chr 19: 40.8 – 40.81 Mb Chr 19: 27.16 – 27.17 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Egl nine homolog 2 is a protein that in humans is encoded by the EGLN2 gene.[5]

The hypoxia inducible factor (HIF) is a transcriptional complex which is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degradation by prolyl hydroxylation. This gene encodes an enzyme responsible for this posttranslational modification. Multiple alternatively spliced variants, encoding the same protein, have been identified.[5]

References[edit]

Further reading[edit]