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Early growth response 2
Protein EGR2 PDB 1a1i.png
PDB rendering based on 1a1i.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EGR2 ; AT591; CMT1D; CMT4E; KROX20
External IDs OMIM129010 MGI95296 HomoloGene20123 GeneCards: EGR2 Gene
RNA expression pattern
PBB GE EGR2 205249 at tn.png
More reference expression data
Species Human Mouse
Entrez 1959 13654
Ensembl ENSG00000122877 ENSMUSG00000037868
UniProt P11161 P08152
RefSeq (mRNA) NM_000399 NM_010118
RefSeq (protein) NP_000390 NP_034248
Location (UCSC) Chr 10:
62.81 – 62.92 Mb
Chr 10:
67.54 – 67.54 Mb
PubMed search [1] [2]

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.


The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D,[1] Dejerine–Sottas disease,[2] and Congenital Hypomyelinating Neuropathy[3]


  1. ^ "Entrez Gene: EGR2 early growth response 2 (Krox-20 homolog, Drosophila)". 
  2. ^ Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (Jul 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. 
  3. ^ Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (Apr 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics 18 (4): 382–384. doi:10.1038/ng0498-382. PMID 9537424. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.