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Early growth response 2
Protein EGR2 PDB 1a1i.png
PDB rendering based on 1a1i.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EGR2 ; AT591; CMT1D; CMT4E; KROX20
External IDs OMIM129010 MGI95296 HomoloGene20123 GeneCards: EGR2 Gene
RNA expression pattern
PBB GE EGR2 205249 at tn.png
More reference expression data
Species Human Mouse
Entrez 1959 13654
Ensembl ENSG00000122877 ENSMUSG00000037868
UniProt P11161 P08152
RefSeq (mRNA) NM_000399 NM_010118
RefSeq (protein) NP_000390 NP_034248
Location (UCSC) Chr 10:
62.81 – 62.92 Mb
Chr 10:
67.54 – 67.54 Mb
PubMed search [1] [2]

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene.


The early growth response protein 2 is a transcription factor with three tandem C2H2-type zinc fingers. Mutations in this gene are associated with the autosomal dominant Charcot-Marie-Tooth disease, type 1D,[1] Dejerine–Sottas disease,[2] and Congenital Hypomyelinating Neuropathy.[3] Two studies have linked EGR2 expression to proliferation of osteoprogenitors [4] and cell lines derived from Ewing sarcoma, which is a highly aggressive bone-associated cancer. [5]


  1. ^ "Entrez Gene: EGR2 early growth response 2 (Krox-20 homolog, Drosophila)". 
  2. ^ Boerkoel CF, Takashima H, Bacino CA, Daentl D, Lupski JR (Jul 2001). "EGR2 mutation R359W causes a spectrum of Dejerine-Sottas neuropathy". Neurogenetics 3 (3): 153–7. doi:10.1007/s100480100107. PMID 11523566. 
  3. ^ Warner LE, Mancias P, Butler IJ, McDonald CM, Keppen L, Koob KG, Lupski JR (Apr 1998). "Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies". Nature Genetics 18 (4): 382–384. doi:10.1038/ng0498-382. PMID 9537424. 
  4. ^ Chandra, Abhishek; Lan, Shenghui; Zhu, Ji; Siclari, Valerie A.; Qin, Ling (2013-07-12). "Epidermal Growth Factor Receptor (EGFR) Signaling Promotes Proliferation and Survival in Osteoprogenitors by Increasing Early Growth Response 2 (EGR2) Expression". Journal of Biological Chemistry 288 (28): 20488–20498. doi:10.1074/jbc.M112.447250. ISSN 0021-9258. PMC 3711314. PMID 23720781. 
  5. ^ Grünewald, Thomas G P; Bernard, Virginie; Gilardi-Hebenstreit, Pascale; Raynal, Virginie; Surdez, Didier; Aynaud, Marie-Ming; Mirabeau, Olivier; Cidre-Aranaz, Florencia; Tirode, Franck. "Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite". Nature Genetics 47 (9): 1073–1078. doi:10.1038/ng.3363. PMC 4591073. PMID 26214589. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.