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Early growth response 3
Symbols EGR3 ; EGR-3; PILOT
External IDs OMIM602419 MGI1306780 HomoloGene37923 GeneCards: EGR3 Gene
RNA expression pattern
PBB GE EGR3 206115 at tn.png
More reference expression data
Species Human Mouse
Entrez 1960 13655
Ensembl ENSG00000179388 ENSMUSG00000033730
UniProt Q06889 P43300
RefSeq (mRNA) NM_001199880 NM_001289925
RefSeq (protein) NP_001186809 NP_001276854
Location (UCSC) Chr 8:
22.69 – 22.69 Mb
Chr 14:
70.08 – 70.08 Mb
PubMed search [1] [2]

Early growth response protein 3 is a protein that in humans is encoded by the EGR3 gene.[1][2][3]

The gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controlling biological rhythm. It may also play a role in muscle development.[3]


  1. ^ Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Le Beau MM, Sukhatme VP (Aug 1991). "EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors". Oncogene 6 (6): 917–28. PMID 1906159. 
  2. ^ Yang Y, Dong B, Mittelstadt PR, Xiao H, Ashwell JD (May 2002). "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem 277 (22): 19482–19487. doi:10.1074/jbc.M201687200. PMID 11909874. 
  3. ^ a b "Entrez Gene: EGR3 early growth response 3". 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.