EHD1

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EHD1
Protein EHD1 PDB 2JQ6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EHD1, H-PAST, HPAST1, PAST, PAST1, EH domain containing 1
External IDs MGI: 1341878 HomoloGene: 81678 GeneCards: EHD1
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for EHD1
Genomic location for EHD1
Band 11q13.1 Start 64,851,642 bp[1]
End 64,888,296 bp[1]
RNA expression pattern
PBB GE EHD1 208112 x at fs.png

PBB GE EHD1 209038 s at fs.png

PBB GE EHD1 209037 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282444
NM_001282445
NM_006795

NM_010119

RefSeq (protein)

NP_001269373
NP_001269374
NP_006786

NP_034249

Location (UCSC) Chr 11: 64.85 – 64.89 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1 gene[4] belonging to the EHD protein family.

Function[edit]

This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.[4]

Interactions[edit]

EHD1 has been shown to interact with Insulin-like growth factor 1 receptor[5] and SNAP29.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110047 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ a b "Entrez Gene: EHD1 EH-domain containing 1". 
  5. ^ a b Rotem-Yehudar, R; Galperin E; Horowitz M (Aug 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. United States. 276 (35): 33054–60. doi:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532. 

Further reading[edit]