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EH-domain containing 1
Protein EHD1 PDB 2JQ6.png
Rendering based on PDB 2JQ6​.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM605888 MGI1341878 HomoloGene81678 GeneCards: EHD1 Gene
RNA expression pattern
PBB GE EHD1 209037 s at tn.png
PBB GE EHD1 208112 x at tn.png
PBB GE EHD1 209038 s at tn.png
More reference expression data
Species Human Mouse
Entrez 10938 13660
Ensembl ENSG00000110047 ENSMUSG00000024772
UniProt Q9H4M9 Q9WVK4
RefSeq (mRNA) NM_001282444 NM_010119
RefSeq (protein) NP_001269373 NP_034249
Location (UCSC) Chr 11:
64.85 – 64.89 Mb
Chr 19:
6.28 – 6.3 Mb
PubMed search [1] [2]

EH domain-containing protein 1, also known as testilin or PAST homolog 1 (PAST1), is a protein that in humans is encoded by the EHD1gene.[1] belonging to the EHD protein family.


This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.[1]


EHD1 has been shown to interact with Insulin-like growth factor 1 receptor[2] and SNAP29.[2]


  1. ^ a b "Entrez Gene: EHD1 EH-domain containing 1". 
  2. ^ a b Rotem-Yehudar, R; Galperin E; Horowitz M (Aug 2001). "Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29". J. Biol. Chem. (United States) 276 (35): 33054–60. doi:10.1074/jbc.M009913200. ISSN 0021-9258. PMID 11423532. 

Further reading[edit]