EHF (gene)

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EHF
Identifiers
AliasesEHF, ESE3, ESE3B, ESEJ, ETS homologous factor
External IDsMGI: 1270840 HomoloGene: 7301 GeneCards: EHF
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for EHF
Genomic location for EHF
Band11p13Start34,621,093 bp[1]
End34,661,057 bp[1]
RNA expression pattern
PBB GE EHF 219850 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001206615
NM_001206616
NM_012153

NM_007914

RefSeq (protein)

NP_001193544
NP_001193545
NP_036285

NP_031940

Location (UCSC)Chr 11: 34.62 – 34.66 MbChr 2: 103.26 – 103.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ETS homologous factor is a protein that in humans is encoded by the EHF gene.[5][6] This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis.[6]

Further reading[edit]

Cangemi, R., Mensah, A., Albertini, V., Jain, A., Mello-Grand, M., Chiorino, G., Catapano, C.V. & Carbone, G.M. Reduced expression and tumor suppressor function of the ETS transcription factor ESE-3 in prostate cancer. Oncogene 27, 2877-2885 (2008).

Albino D, Longoni N, Curti L, Mello-Grand M, Pinton S, Civenni G, Thalmann G, D'Ambrosio G, Sarti M, Sessa F, Chiorino G, Catapano CV, Carbone GM. ESE3/EHF controls epithelial cell differentiation and its loss leads to prostate tumors with mesenchymal and stem-like features. Cancer Res. 2012 Jun 1;72(11):2889-900.

Kunderfranco, P., Mello-Grand, M., Cangemi, R., Pellini, S., Mensah, A., Albertini, V., Malek, A., Chiorino, G., Catapano, C.V. & Carbone, G.M. ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer. PLoS One 5, e10547 (2010).

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135373 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000012350 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kleinbaum LA, Duggan C, Ferreira E, Coffey GP, Buttice G, Burton FH (Nov 1999). "Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF". Biochem Biophys Res Commun. 264 (1): 119–26. doi:10.1006/bbrc.1999.1493. PMID 10527851. 
  6. ^ a b "Entrez Gene: EHF ets homologous factor". 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.