EHMT1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
EHMT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EHMT1, EUHMTASE1, Eu-HMTase1, FP13812, GLP, GLP1, KMT1D, bA188C12.1, euchromatic histone lysine methyltransferase 1
External IDs MGI: 1924933 HomoloGene: 11698 GeneCards: EHMT1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001145527
NM_024757

NM_001012518
NM_001109686
NM_001109687
NM_172545

RefSeq (protein)

NP_001138999
NP_079033

Location (UCSC) Chr 9: 137.62 – 137.87 Mb Chr 2: 24.79 – 24.92 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a protein that in humans is encoded by the EHMT1 gene.[3]

Function[edit]

The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition.[3]

Clinical significance[edit]

Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome).[3]

References[edit]

Further reading[edit]