EIF2AK1

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EIF2AK1
Identifiers
Aliases EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2 alpha kinase 1
External IDs MGI: 1353448 HomoloGene: 8290 GeneCards: EIF2AK1
RNA expression pattern
PBB GE EIF2AK1 217735 s at tn.png

PBB GE EIF2AK1 217736 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014413
NM_001134335

NM_013557

RefSeq (protein)

NP_001127807.1
NP_055228.2
NP_055228.2

NP_038585.2

Location (UCSC) Chr 7: 6.02 – 6.06 Mb Chr 5: 143.82 – 143.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.[3][4][5]

The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chen JJ, London IM (May 1995). "Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase". Trends Biochem Sci. 20 (3): 105–8. doi:10.1016/S0968-0004(00)88975-6. PMID 7709427. 
  4. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  5. ^ a b "Entrez Gene: EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1". 

Further reading[edit]