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Eukaryotic translation initiation factor 2-alpha kinase 1
Symbols EIF2AK1 ; HCR; HRI
External IDs OMIM613635 MGI1353448 HomoloGene8290 IUPHAR: 2015 ChEMBL: 6029 GeneCards: EIF2AK1 Gene
EC number
RNA expression pattern
PBB GE EIF2AK1 217736 s at tn.png
PBB GE EIF2AK1 217735 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27102 15467
Ensembl ENSG00000086232 ENSMUSG00000029613
UniProt Q9BQI3 Q9Z2R9
RefSeq (mRNA) NM_001134335 NM_013557
RefSeq (protein) NP_001127807 NP_038585
Location (UCSC) Chr 7:
6.02 – 6.06 Mb
Chr 5:
143.82 – 143.9 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.[1][2][3]

The HRI gene is localized to 7p22 where its 3' end slightly overlaps the 3' end of the gene JTV1. The two genes are transcribed from opposite strands. Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2. Its kinase activity is induced by low levels of heme and inhibited by the presence of heme.[3]


  1. ^ Chen JJ, London IM (May 1995). "Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase". Trends Biochem Sci 20 (3): 105–8. doi:10.1016/S0968-0004(00)88975-6. PMID 7709427. 
  2. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  3. ^ a b "Entrez Gene: EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1". 

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