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Eukaryotic translation initiation factor 2 alpha kinase 4
Symbols EIF2AK4 ; GCN2; PVOD2
External IDs OMIM609280 MGI1353427 HomoloGene40891 ChEMBL: 5358 GeneCards: EIF2AK4 Gene
EC number
Species Human Mouse
Entrez 440275 27103
Ensembl ENSG00000128829 ENSMUSG00000005102
UniProt Q9P2K8 Q9QZ05
RefSeq (mRNA) NM_001013703 NM_001177806
RefSeq (protein) NP_001013725 NP_001171277
Location (UCSC) Chr 15:
39.93 – 40.04 Mb
Chr 2:
118.39 – 118.48 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.[1][2]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM][2]

See also[edit]


  1. ^ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem 265 (2): 754–62. doi:10.1046/j.1432-1327.1999.00780.x. PMID 10504407. 
  2. ^ a b "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4". 

Further reading[edit]