EIF2AK4

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EIF2AK4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EIF2AK4, GCN2, PVOD2, eukaryotic translation initiation factor 2 alpha kinase 4
External IDs MGI: 1353427 HomoloGene: 40891 GeneCards: EIF2AK4
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001013703

NM_001177806
NM_013719

RefSeq (protein)

NP_001013725

NP_001171277
NP_038747

Location (UCSC) Chr 15: 39.93 – 40.04 Mb Chr 2: 118.39 – 118.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 4 is an enzyme that in humans is encoded by the EIF2AK4 gene.[3][4]

EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999).[supplied by OMIM][4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Berlanga JJ, Santoyo J, De Haro C (Nov 1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase". Eur J Biochem. 265 (2): 754–62. PMID 10504407. doi:10.1046/j.1432-1327.1999.00780.x. 
  4. ^ a b "Entrez Gene: EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4". 

Further reading[edit]