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Eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF2B1 ; EIF2B; EIF2BA
External IDs OMIM606686 MGI2384802 HomoloGene1080 GeneCards: EIF2B1 Gene
RNA expression pattern
PBB GE EIF2B1 201632 at tn.png
More reference expression data
Species Human Mouse
Entrez 1967 209354
Ensembl ENSG00000111361 ENSMUSG00000029388
UniProt Q14232 Q99LC8
RefSeq (mRNA) NM_001414 NM_145371
RefSeq (protein) NP_001405 NP_663346
Location (UCSC) Chr 12:
123.62 – 123.63 Mb
Chr 5:
124.57 – 124.58 Mb
PubMed search [1] [2]

Translation initiation factor eIF-2B subunit alpha is a protein that in humans is encoded by the EIF2B1 gene.[1]


EIF2B1 has been shown to interact with EIF2B5.[2][3]


  1. ^ "Entrez Gene: EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa". 
  2. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  3. ^ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531. 

Further reading[edit]