EIF2B2

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EIF2B2
Identifiers
Aliases EIF2B2, EIF-2Bbeta, EIF2B, eukaryotic translation initiation factor 2B subunit beta
External IDs MGI: 2145118 HomoloGene: 6507 GeneCards: EIF2B2
RNA expression pattern
PBB GE EIF2B2 202461 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014239

NM_145445

RefSeq (protein)

NP_055054

NP_663420.1
NP_663420

Location (UCSC) Chr 14: 75 – 75.01 Mb Chr 12: 85.22 – 85.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Translation initiation factor eIF-2B subunit beta is a protein that in humans is encoded by the EIF2B2 gene.[3][4]

Function[edit]

Eukaryotic initiation factor-2B (EIF2B) is a GTP exchange protein essential for protein synthesis. It consists of alpha (EIF2B1; MIM 606686), beta (EIF2B2), gamma (EIF2B3; MIM 606273), delta (EIF2B4; MIM 606687), and epsilon (EIF2B5; MIM 603945) subunits. EIF2B activates its EIF2 (see MIM 603907) substrate by exchanging EIF2-bound GDP for GTP.[4]

Interactions[edit]

EIF2B2 has been shown to interact with EIF2B5[5] and NCK1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yang W, Hinnebusch AG (December 1996). "Identification of a regulatory subcomplex in the guanine nucleotide exchange factor eIF2B that mediates inhibition by phosphorylated eIF2". Mol Cell Biol. 16 (11): 6603–16. PMC 231662Freely accessible. PMID 8887689. 
  4. ^ a b "Entrez Gene: EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa". 
  5. ^ Anthony TG, Fabian JR, Kimball SR, Jefferson LS (June 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochim. Biophys. Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531. 
  6. ^ Kebache S, Zuo D, Chevet E, Larose L (April 2002). "Modulation of protein translation by Nck-1". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5406–5411. doi:10.1073/pnas.082483399. PMC 122782Freely accessible. PMID 11959995. 

Further reading[edit]