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Available structures
PDB Ortholog search: PDBe RCSB
Aliases EIF2B5, CACH, CLE, EIF-2B, EIF2Bepsilon, LVWM, eukaryotic translation initiation factor 2B subunit epsilon
External IDs MGI: 2446176 HomoloGene: 2903 GeneCards: EIF2B5
RNA expression pattern
PBB GE EIF2B5 212351 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 3: 184.14 – 184.15 Mb Chr 16: 20.5 – 20.51 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Translation initiation factor eIF-2B subunit epsilon is a protein that in humans is encoded by the EIF2B5 gene.[3][4]


EIF2B5 has been shown to interact with EIF2B2[5] and EIF2B1.[5][6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS, Matts RL (Jul 1996). "Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human". Biochimica et Biophysica Acta. 1307 (3): 309–17. doi:10.1016/0167-4781(96)00054-1. PMID 8688466. 
  4. ^ "Entrez Gene: EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa". 
  5. ^ a b Anthony TG, Fabian JR, Kimball SR, Jefferson LS (Jun 2000). "Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation". Biochimica et Biophysica Acta. 1492 (1): 56–62. doi:10.1016/S0167-4781(00)00062-2. PMID 10858531. 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931. 

Further reading[edit]