EIF2S2

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EIF2S2
Identifiers
Aliases EIF2S2, EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta, eukaryotic translation initiation factor 2 subunit beta
External IDs MGI: 1914454 HomoloGene: 2904 GeneCards: EIF2S2
RNA expression pattern
PBB GE EIF2S2 208726 s at fs.png

PBB GE EIF2S2 208725 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003908
NM_001316363
NM_001316364

NM_026030

RefSeq (protein)

NP_001303292
NP_001303293
NP_003899

NP_080306.1
NP_080306

Location (UCSC) Chr 20: 34.09 – 34.11 Mb Chr 2: 154.87 – 154.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 2 subunit 2 (eIF2β) is a protein that in humans is encoded by the EIF2S2 gene.[3][4]

Function[edit]

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β, this article), and gamma (γ), with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the eIF2 complex for another round of initiation.[4]

Regulation[edit]

Both eIF2α and eIF2β expression is regulated by the NRF1 transcription factor.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pathak VK, Nielsen PJ, Trachsel H, Hershey JW (Sep 1988). "Structure of the beta subunit of translational initiation factor eIF-2". Cell. 54 (5): 633–9. doi:10.1016/S0092-8674(88)80007-2. PMID 3044606. 
  4. ^ a b "Entrez Gene: EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa". 
  5. ^ Chiorini JA, Miyamoto S, Harkin SJ, Safer B (February 1999). "Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter". J. Biol. Chem. 274 (7): 4195–201. doi:10.1074/jbc.274.7.4195. PMID 9933616. 

Further reading[edit]