EIF2S3

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EIF2S3
Identifiers
Aliases EIF2S3, EIF2, EIF2G, EIF2gamma, eIF-2gA, eukaryotic translation initiation factor 2 subunit gamma
External IDs MGI: 1349431 HomoloGene: 90888 GeneCards: EIF2S3
RNA expression pattern
PBB GE EIF2S3 205321 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001415

NM_012010

RefSeq (protein)

NP_001406.1
NP_001406.1

NP_036140.1

Location (UCSC) Chr X: 24.05 – 24.08 Mb Chr X: 94.19 – 94.21 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.[3][3][4][4][5]

Function[edit]

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.[5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem. 269 (5): 3415–22. PMID 8106381. 
  4. ^ a b Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet. 7 (11): 1725–37. doi:10.1093/hmg/7.11.1725. PMID 9736774. 
  5. ^ a b "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". 

Further reading[edit]