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Available structures
PDB Ortholog search: PDBe RCSB
Aliases EIF3K, EIF3-p28, EIF3S12, HSPC029, M9, MSTP001, PLAC-24, PLAC24, PRO1474, PTD001, ARG134, eukaryotic translation initiation factor 3 subunit K
External IDs MGI: 1921080 HomoloGene: 8292 GeneCards: EIF3K
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for EIF3K
Genomic location for EIF3K
Band 19q13.2 Start 38,619,082 bp[1]
End 38,636,955 bp[1]
RNA expression pattern
PBB GE EIF3S12 212716 s at fs.png

PBB GE EIF3S12 210501 x at fs.png

PBB GE EIF3S12 221494 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 38.62 – 38.64 Mb Chr 19: 28.97 – 28.98 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 3 subunit K is a protein that in humans is encoded by the EIF3K gene.[5][6][7]


The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003).[supplied by OMIM][7]


EIF3K has been shown to interact with Cyclin D3[8] and EIF3A.[6][9]

See also[edit]


  1. ^ a b c ENSG00000282986 GRCh38: Ensembl release 89: ENSG00000178982, ENSG00000282986 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053565 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. PMC 310934Freely accessible. PMID 11042152. doi:10.1101/gr.140200. 
  6. ^ a b Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (Oct 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. PMID 14519125. doi:10.1046/j.1432-1033.2003.03807.x. 
  7. ^ a b "Entrez Gene: EIF3S12 eukaryotic translation initiation factor 3, subunit 12". 
  8. ^ Shen X, Yang Y, Liu W, Sun M, Jiang J, Zong H, Gu J (Aug 2004). "Identification of the p28 subunit of eukaryotic initiation factor 3(eIF3k) as a new interaction partner of cyclin D3". FEBS Lett. 573 (1-3): 139–46. PMID 15327989. doi:10.1016/j.febslet.2004.07.071. 
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. PMC 1847948Freely accessible. PMID 17353931. doi:10.1038/msb4100134. 

Further reading[edit]