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Eukaryotic translation initiation factor 3, subunit E
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF3E ; EIF3-P48; EIF3S6; INT6; eIF3-p46
External IDs OMIM602210 MGI99257 HomoloGene1205 GeneCards: EIF3E Gene
RNA expression pattern
PBB GE EIF3S6 208697 s at tn.png
More reference expression data
Species Human Mouse
Entrez 3646 16341
Ensembl ENSG00000104408 ENSMUSG00000022336
UniProt P60228 P60229
RefSeq (mRNA) NM_001568 NM_008388
RefSeq (protein) NP_001559 NP_032414
Location (UCSC) Chr 8:
108.2 – 108.44 Mb
Chr 15:
43.25 – 43.28 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 3 subunit E is a protein that in humans is encoded by the EIF3E gene.[1][2][3]


EIF3S6 has been shown to interact with:


  1. ^ Miyazaki S, Imatani A, Ballard L, Marchetti A, Buttitta F, Albertsen H, Nevanlinna HA, Gallahan D, Callahan R (January 1998). "The chromosome location of the human homolog of the mouse mammary tumor-associated gene INT6 and its status in human breast carcinomas". Genomics 46 (1): 155–8. doi:10.1006/geno.1997.4996. PMID 9403073.  Check date values in: |year= / |date= mismatch (help)
  2. ^ Asano K, Merrick WC, Hershey JW (October 1997). "The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome". J. Biol. Chem. 272 (38): 23477–80. doi:10.1074/jbc.272.38.23477. PMID 9295280. 
  3. ^ "Entrez Gene: EIF3S6 Eukaryotic translation initiation factor 3, subunit 6 48kDa". 
  4. ^ Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/s0888-7543(03)00235-0. PMID 14667819. 
  5. ^ a b Hoareau Alves K, Bochard V, Réty S, Jalinot P (September 2002). "Association of the mammalian proto-oncoprotein Int-6 with the three protein complexes eIF3, COP9 signalosome and 26S proteasome". FEBS Lett. 527 (1-3): 15–21. doi:10.1016/s0014-5793(02)03147-2. PMID 12220626. 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  7. ^ Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003). "Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3". Eur. J. Biochem. 270 (20): 4133–9. doi:10.1046/j.1432-1033.2003.03807.x. PMID 14519125. 
  8. ^ Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P (December 2001). "The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3". J. Biol. Chem. 276 (49): 45988–95. doi:10.1074/jbc.M104966200. PMID 11590142. 
  9. ^ Morris-Desbois C, Bochard V, Reynaud C, Jalinot P (October 1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell. Sci. 112 ( Pt 19): 3331–42. PMID 10504338. 

Further reading[edit]