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Protein EIF4A3 PDB 2hxy.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3
External IDs MGI: 1923731 HomoloGene: 5602 GeneCards: 9775
RNA expression pattern
PBB GE EIF4A3 201303 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 80.14 – 80.15 Mb Chr 11: 119.29 – 119.3 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.[3][4][5]


This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, Grimm R, Sauermann G (Feb 2000). "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A". Biochem Biophys Res Commun. 267 (1): 339–44. doi:10.1006/bbrc.1999.1973. PMID 10623621. 
  4. ^ Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, Dreyfuss G (Jan 2004). "eIF4A3 is a novel component of the exon junction complex". RNA. 10 (2): 200–9. doi:10.1261/rna.5230104. PMC 1370532free to read. PMID 14730019. 
  5. ^ a b "Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3". 

Further reading[edit]