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Eukaryotic translation initiation factor 4A3
Protein EIF4A3 PDB 2hxy.png
PDB rendering based on 2hxy.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF4A3 ; DDX48; MUK34; NMP265; NUK34; RCPS; eIF4AIII
External IDs OMIM608546 MGI1923731 HomoloGene5602 GeneCards: EIF4A3 Gene
EC number
RNA expression pattern
PBB GE EIF4A3 201303 at tn.png
More reference expression data
Species Human Mouse
Entrez 9775 192170
Ensembl ENSG00000141543 ENSMUSG00000025580
UniProt P38919 Q91VC3
RefSeq (mRNA) NM_014740 NM_138669
RefSeq (protein) NP_055555 NP_619610
Location (UCSC) Chr 17:
80.14 – 80.15 Mb
Chr 11:
119.29 – 119.3 Mb
PubMed search [1] [2]

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.[1][2][3]


This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4A-I and eIF4A-II, two other members of the DEAD box protein family.[3]


  1. ^ Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, Grimm R, Sauermann G (Feb 2000). "A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A". Biochem Biophys Res Commun 267 (1): 339–44. doi:10.1006/bbrc.1999.1973. PMID 10623621. 
  2. ^ Chan CC, Dostie J, Diem MD, Feng W, Mann M, Rappsilber J, Dreyfuss G (Jan 2004). "eIF4A3 is a novel component of the exon junction complex". RNA 10 (2): 200–9. doi:10.1261/rna.5230104. PMC 1370532. PMID 14730019. 
  3. ^ a b "Entrez Gene: EIF4A3 eukaryotic translation initiation factor 4A, isoform 3". 

Further reading[edit]