EIF4B

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EIF4B
Protein EIF4B PDB 1wi8.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4B, EIF-4B, PRO1843, eukaryotic translation initiation factor 4B
External IDsMGI: 95304 HomoloGene: 83162 GeneCards: EIF4B
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for EIF4B
Genomic location for EIF4B
Band12q13.13Start53,006,158 bp[1]
End53,042,209 bp[1]
RNA expression pattern
PBB GE EIF4B 211937 at fs.png

PBB GE EIF4B 211938 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300821
NM_001417
NM_018507
NM_001330654

NM_145625

RefSeq (protein)

NP_001287750
NP_001317583
NP_001408

NP_663600

Location (UCSC)Chr 12: 53.01 – 53.04 MbChr 15: 102.07 – 102.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.[5]

Interactions[edit]

EIF4B has been shown to interact and stimulate the activity of EIF4A and binds the eIF3 complex through the eIF3A subunit.[6] This will result in the recruitment of the Eukaryotic small ribosomal subunit (40S) to the mRNA which will in turn set the stage for the later steps leading to elongation.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000063046 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058655 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: EIF4B eukaryotic translation initiation factor 4B".
  6. ^ Merrick WC (Oct 2015). "eIF4F: a retrospective". The Journal of Biological Chemistry. 290 (40): 24091–9. doi:10.1074/jbc.R115.675280. PMC 4591800. PMID 26324716.

External links[edit]

Further reading[edit]