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Protein-coding gene in the species Homo sapiens
Eukaryotic translation initiation factor 4E transporter is a protein that in humans is encoded by the EIF4ENIF1 gene .[5] [6]
The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic;its own nuclear import is regulated by a nuclear localization signal and nuclear export signals.[6]
Interactions [ edit ] EIF4ENIF1 has been shown to interact with EIF4E .[5]
References [ edit ]
^ a b c GRCh38: Ensembl release 89: ENSG00000184708 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020454 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N (Aug 2000). "A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E" . EMBO J . 19 (12): 3142–56. doi :10.1093/emboj/19.12.3142 . PMC 203362 PMID 10856257 . ^ a b "Entrez Gene: EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1" .
Further reading [ edit ]
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins". Biochem. Biophys. Res. Commun . 312 (4): 1185–90. doi :10.1016/j.bbrc.2003.11.049 . PMID 14651998 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain" . Mol. Cell. Proteomics . 3 (11): 1093–101. doi :10.1074/mcp.M400085-MCP200 PMID 15345747 . Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome" . Genome Biol . 5 (10): R84. doi :10.1186/gb-2004-5-10-r84 PMC 545604 PMID 15461802 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Andrei MA, Ingelfinger D, Heintzmann R, et al. (2005). "A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies" . RNA . 11 (5): 717–27. doi :10.1261/rna.2340405 . PMC 1370757 PMID 15840819 . Ferraiuolo MA, Basak S, Dostie J, et al. (2005). "A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay" . J. Cell Biol . 170 (6): 913–24. doi :10.1083/jcb.200504039 . PMC 2171455 PMID 16157702 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies" . PLOS Pathog . 2 (5): e41. doi :10.1371/journal.ppat.0020041 PMC 1458959 PMID 16699599 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions" . Genome Res . 17 (6): 746–59. doi :10.1101/gr.5660607 . PMC 1891335 PMID 17567994 .
