Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
^Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme". Genes Dev.11 (3): 321–33. doi:10.1101/gad.11.3.321. PMID9030685.
Shaughnessy JD, Jenkins NA, Copeland NG (1997). "cDNA cloning, expression analysis, and chromosomal localization of a gene with high homology to wheat eIF-(iso)4F and mammalian eIF-4G". Genomics39 (2): 192–7. doi:10.1006/geno.1996.4502. PMID9027506.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK (1999). "Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G". Mol. Cell3 (6): 707–16. doi:10.1016/S1097-2765(01)80003-4. PMID10394359.
Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK (2001). "A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery". Mol. Cell7 (1): 193–203. doi:10.1016/S1097-2765(01)00167-8. PMID11172724.
Marissen WE, Gradi A, Sonenberg N, Lloyd RE (2000). "Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis". Cell Death Differ.7 (12): 1234–43. doi:10.1038/sj.cdd.4400750. PMID11175261.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol.21 (5): 566–9. doi:10.1038/nbt810. PMID12665801.
Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y (2003). "[Effect of beta-carotene on gene expression of breast cancer cells]". Ai Zheng22 (4): 380–4. PMID12703993.
Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM (2003). "Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I". J. Biol. Chem.278 (49): 48570–9. doi:10.1074/jbc.M308781200. PMID14507913.