EIF4G2

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EIF4G2
Protein EIF4G2 PDB 3D3M.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EIF4G2, AAG1, DAP5, NAT1, P97, eukaryotic translation initiation factor 4 gamma 2
External IDs MGI: 109207 HomoloGene: 37477 GeneCards: EIF4G2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001418
NM_001042559
NM_001172705

NM_001040131
NM_013507

RefSeq (protein)

NP_001036024
NP_001166176
NP_001409

NP_001035221.1
NP_038535.2
NP_001035221
NP_038535

Location (UCSC) Chr 11: 10.8 – 10.81 Mb Chr 7: 111.07 – 111.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.[3][4]

Function[edit]

Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by the eIF4G2 gene shares similarity with the C-terminal region of eIF4G1 that contains the binding sites for eIF4A and eIF3. eIF4G2 additionally contains a binding site for eIF4E at the N-terminus. Unlike eIF4G1, which supports cap-dependent and independent translation, the eIF4G2 gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[5]

Interactions[edit]

EIF4G2 has been shown to interact with EIF3A.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme". Genes Dev. 11 (3): 321–33. doi:10.1101/gad.11.3.321. PMID 9030685. 
  4. ^ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (March 1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death". Mol. Cell. Biol. 17 (3): 1615–25. doi:10.1128/mcb.17.3.1615. PMC 231887Freely accessible. PMID 9032289. 
  5. ^ "Entrez Gene: EIF4G2 eukaryotic translation initiation factor 4 gamma, 2". 
  6. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (January 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501Freely accessible. PMID 9418880. 
  7. ^ Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (January 2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation". Mol. Cell. Biol. 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. PMC 85113Freely accessible. PMID 10611228. 

Further reading[edit]