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Eukaryotic translation initiation factor 4 gamma, 2
Protein EIF4G2 PDB 3D3M.png
Rendering based on PDB 3D3M.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols EIF4G2 ; AAG1; DAP5; NAT1; P97
External IDs OMIM602325 MGI109207 HomoloGene37477 GeneCards: EIF4G2 Gene
Species Human Mouse
Entrez 1982 13690
Ensembl ENSG00000110321 ENSMUSG00000005610
UniProt P78344 Q62448
RefSeq (mRNA) NM_001042559 NM_001040131
RefSeq (protein) NP_001036024 NP_001035221
Location (UCSC) Chr 11:
10.8 – 10.81 Mb
Chr 7:
111.07 – 111.08 Mb
PubMed search [1] [2]

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.[1][2]


Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.[3]


EIF4G2 has been shown to interact with EIF3A.[4][5]


  1. ^ Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme". Genes Dev. 11 (3): 321–33. doi:10.1101/gad.11.3.321. PMID 9030685. 
  2. ^ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (March 1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death". Mol. Cell. Biol. 17 (3): 1615–25. PMC 231887. PMID 9032289. 
  3. ^ "Entrez Gene: EIF4G2 eukaryotic translation initiation factor 4 gamma, 2". 
  4. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (January 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. PMC 121501. PMID 9418880. 
  5. ^ Henis-Korenblit S, Strumpf NL, Goldstaub D, Kimchi A (January 2000). "A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation". Mol. Cell. Biol. 20 (2): 496–506. doi:10.1128/MCB.20.2.496-506.2000. PMC 85113. PMID 10611228. 

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