EIF4G3

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EIF4G3
Protein EIF4G3 PDB 1hu3.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEIF4G3, eIF-4G 3, eIF4G 3, eIF4GII, eukaryotic translation initiation factor 4 gamma 3
External IDsMGI: 1923935 HomoloGene: 2789 GeneCards: EIF4G3
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for EIF4G3
Genomic location for EIF4G3
Band1p36.12Start20,806,292 bp[1]
End21,176,888 bp[1]
RNA expression pattern
PBB GE EIF4G3 201936 s at fs.png

PBB GE EIF4G3 201935 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198801
NM_001198802
NM_001198803
NM_003760

NM_001256195
NM_001256198
NM_172703
NM_001355699
NM_001355700

RefSeq (protein)

NP_001185730
NP_001185731
NP_001185732
NP_003751

Location (UCSC)Chr 1: 20.81 – 21.18 MbChr 4: 137.99 – 138.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 3 is a protein that in humans is encoded by the EIF4G3 gene.[5][6] The gene encodes a protein that functions in translation by aiding the assembly of the ribosome onto the messenger RNA template.[7] Confusingly, this protein is usually referred to as eIF4GII, as although EIF4G3 is the third gene that is similar to eukaryotic translation initiation factor 4 gamma, the second isoform EIF4G2 is not an active translation initiation factor.[8]

Interactions[edit]

EIF4G3 has been shown to interact with PABPC1.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075151 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028760 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (Jan 1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  6. ^ "Entrez Gene: EIF4G3 eukaryotic translation initiation factor 4 gamma, 3".
  7. ^ Gingras AC, Raught B, Sonenberg N (1999). "eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation". Annu. Rev. Biochem. 68: 913–63. doi:10.1146/annurev.biochem.68.1.913. PMID 10872469.
  8. ^ Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N (1998). "A novel functional human eukaryotic translation initiation factor 4G". Mol. Cell. Biol. 18 (1): 334–42. doi:10.1128/mcb.18.1.334. PMC 121501. PMID 9418880.
  9. ^ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". EMBO J. 17 (24): 7480–9. doi:10.1093/emboj/17.24.7480. PMC 1171091. PMID 9857202.

Further reading[edit]