EIF4H

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EIF4H
Protein EIF4H PDB 2dng.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EIF4H, WBSCR1, WSCR1, eIF-4H, eukaryotic translation initiation factor 4H
External IDs MGI: 1341822 HomoloGene: 32536 GeneCards: EIF4H
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022170
NM_031992

NM_033561
NM_001312867

RefSeq (protein)

NP_071496
NP_114381

NP_001299796.1
NP_291039.1
NP_001299796
NP_291039

Location (UCSC) Chr 7: 74.17 – 74.2 Mb Chr 5: 134.62 – 134.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[3][4][5]

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.[5]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem. 273 (13): 7579–87. doi:10.1074/jbc.273.13.7579. PMID 9516461. 
  4. ^ Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol. 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC 387725Freely accessible. PMID 15078951. 
  5. ^ a b "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H". 
  6. ^ "Early discovery may aid search for anti-aging drugs". 2010. 

Further reading[edit]