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Aliases EIF5B, IF2, eukaryotic translation initiation factor 5B
External IDs MGI: 2441772 HomoloGene: 134613 GeneCards: EIF5B
RNA expression pattern
PBB GE EIF5B 201027 s at fs.png

PBB GE EIF5B 201025 at fs.png

PBB GE EIF5B 201024 x at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 2: 99.34 – 99.4 Mb Chr 1: 38 – 38.06 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 5B is a protein that in humans is encoded by the EIF5B gene.[3][4][5]

Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lee JH, Choi SK, Roll-Mecak A, Burley SK, Dever TE (May 1999). "Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2". Proc Natl Acad Sci U S A. 96 (8): 4342–7. doi:10.1073/pnas.96.8.4342. PMC 16334Freely accessible. PMID 10200264. 
  4. ^ Wilson SA, Sieiro-Vazquez C, Edwards NJ, Iourin O, Byles ED, Kotsopoulou E, Adamson CS, Kingsman SM, Kingsman AJ, Martin-Rendon E (Oct 1999). "Cloning and characterization of hIF2, a human homologue of bacterial translation initiation factor 2, and its interaction with HIV-1 matrix". Biochem J. 342. ( Pt 1): 97–103. PMC 1220441Freely accessible. PMID 10432305. 
  5. ^ a b "Entrez Gene: EIF5B eukaryotic translation initiation factor 5B". 

Further reading[edit]