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Aliases EIF6, CAB, EIF3A, ITGB4BP, b(2)gcn, eIF-6, p27(BBP), p27BBP, eukaryotic translation initiation factor 6
External IDs MGI: 1196288 HomoloGene: 7135 GeneCards: EIF6
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for EIF6
Genomic location for EIF6
Band 20q11.22 Start 35,278,907 bp[1]
End 35,284,985 bp[1]
RNA expression pattern
PBB GE ITGB4BP 78047 s at fs.png

PBB GE ITGB4BP 210213 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC) Chr 20: 35.28 – 35.28 Mb Chr 20: 155.82 – 155.83 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human gene.[5]

Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and catalyzes the association of the 40S and 60S ribosomal subunits along with eIF5 bound to GTP. Multiple transcript variants encoding several different isoforms have been found for this gene.[5]


EIF6 has been shown to interact with FHL2,[6] ITGB4[7] and GNB2L1.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000242372 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027613 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: ITGB4BP integrin beta 4 binding protein". 
  6. ^ Wixler, V; Geerts D; Laplantine E; Westhoff D; Smyth N; Aumailley M; Sonnenberg A; Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. UNITED STATES. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. ISSN 0021-9258. PMID 10906324. 
  7. ^ Biffo, S; Sanvito F; Costa S; Preve L; Pignatelli R; Spinardi L; Marchisio P C (November 1997). "Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells". J. Biol. Chem. UNITED STATES. 272 (48): 30314–21. doi:10.1074/jbc.272.48.30314. ISSN 0021-9258. PMID 9374518. 
  8. ^ Ceci, Marcello; Gaviraghi Cristina; Gorrini Chiara; Sala Leonardo A; Offenhäuser Nina; Marchisio Pier Carlo; Biffo Stefano (December 2003). "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly". Nature. England. 426 (6966): 579–84. doi:10.1038/nature02160. PMID 14654845. 

Further reading[edit]