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E74-like factor 5 (ets domain transcription factor)
Protein ELF5 PDB 1wwx.png
PDB rendering based on 1wwx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ELF5 ; ESE2
External IDs OMIM605169 MGI1335079 HomoloGene7702 GeneCards: ELF5 Gene
RNA expression pattern
PBB GE ELF5 220625 s at tn.png
PBB GE ELF5 220624 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2001 13711
Ensembl ENSG00000135374 ENSMUSG00000027186
UniProt Q9UKW6 Q8VDK3
RefSeq (mRNA) NM_001243080 NM_001145813
RefSeq (protein) NP_001230009 NP_001139285
Location (UCSC) Chr 11:
34.48 – 34.51 Mb
Chr 2:
103.41 – 103.45 Mb
PubMed search [1] [2]

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans.[1] In humans it is also called ESE2.

The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[1]


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This article incorporates text from the United States National Library of Medicine, which is in the public domain.