ELF5

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ELF5
Protein ELF5 PDB 1wwx.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesELF5, ESE2, E74 like ETS transcription factor 5
External IDsHomoloGene: 7702 GeneCards: ELF5
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for ELF5
Genomic location for ELF5
Band11p13Start34,478,793 bp[1]
End34,513,805 bp[1]
RNA expression pattern
PBB GE ELF5 220625 s at fs.png

PBB GE ELF5 220624 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198381
NM_001243080
NM_001243081
NM_001422

n/a

RefSeq (protein)

NP_001230009
NP_001230010
NP_001413
NP_938195

n/a

Location (UCSC)Chr 11: 34.48 – 34.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans.[3] In humans it is also called ESE2.

Function[edit]

The protein encoded by this gene is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[3]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000135374 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ a b "Entrez Gene: ELF5 E74-like factor 5 (ets domain transcription factor)".

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.