EMCN

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EMCN
Identifiers
AliasesEMCN, EMCN2, MUC14, endomucin
External IDsMGI: 1891716 HomoloGene: 9438 GeneCards: EMCN
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for EMCN
Genomic location for EMCN
Band4q24Start100,395,341 bp[1]
End100,880,126 bp[1]
RNA expression pattern
PBB GE EMCN 219436 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001159694
NM_016242

NM_001163522
NM_016885

RefSeq (protein)

NP_001153166
NP_057326

NP_001156994
NP_058581

Location (UCSC)Chr 4: 100.4 – 100.88 MbChr 3: 137.34 – 137.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Endomucin is a protein that in humans is encoded by the EMCN gene.[5][6][7] Endomucin is a marker for endothelial cells[8] and hematopoietic stem cells.[9]

Function[edit]

EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.[5][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164035 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054690 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b Kinoshita M, Nakamura T, Ihara M, Haraguchi T, Hiraoka Y, Tashiro K, Noda M (June 2001). "Identification of human endomucin-1 and -2 as membrane-bound O-sialoglycoproteins with anti-adhesive activity". FEBS Letters. 499 (1–2): 121–6. doi:10.1016/S0014-5793(01)02520-0. PMID 11418125.
  6. ^ Liu C, Shao ZM, Zhang L, Beatty P, Sartippour M, Lane T, Livingston E, Nguyen M (October 2001). "Human endomucin is an endothelial marker". Biochemical and Biophysical Research Communications. 288 (1): 129–36. doi:10.1006/bbrc.2001.5737. PMID 11594763.
  7. ^ a b "Entrez Gene: EMCN endomucin".
  8. ^ 1.Liu, C. et al. Human Endomucin Is an Endothelial Marker. Biochemical and Biophysical Research Communications 288, 129-136 (2001).
  9. ^ Matsubara A.; et al. (2005). "Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development". Journal of Experimental Medicine. 11 (202): 1483. doi:10.1084/jem.20051325. PMC 2213340.

Further reading[edit]