ENSA (gene)

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ENSA
Identifiers
Aliases ENSA, ARPP-19e, endosulfine alpha
External IDs MGI: 1891189 HomoloGene: 37924 GeneCards: ENSA
RNA expression pattern
PBB GE ENSA 221486 at fs.png

PBB GE ENSA 202596 at fs.png

PBB GE ENSA 221487 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001026212
NM_019561

RefSeq (protein)

NP_001021383.1
NP_062507.1
NP_001021383
NP_062507

Location (UCSC) Chr 1: 150.6 – 150.63 Mb Chr 3: 95.62 – 95.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene.[3][4]

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.[4]

References[edit]

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