Prostaglandin EP1 receptor

From Wikipedia, the free encyclopedia
  (Redirected from EP1 receptor)
Jump to: navigation, search
Prostaglandin E receptor 1 (subtype EP1), 42kDa
Symbols PTGER1 ; EP1
External IDs OMIM176802 MGI97793 HomoloGene738 IUPHAR: 340 ChEMBL: 1811 GeneCards: PTGER1 Gene
RNA expression pattern
PBB GE PTGER1 214391 x at tn.png
PBB GE PTGER1 207650 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5731 19216
Ensembl ENSG00000160951 ENSMUSG00000019464
UniProt P34995 P35375
RefSeq (mRNA) NM_000955 NM_013641
RefSeq (protein) NP_000946 NP_038669
Location (UCSC) Chr 19:
14.47 – 14.48 Mb
Chr 8:
83.67 – 83.67 Mb
PubMed search [1] [2]

Prostaglandin E1 receptor 1 (EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.[1]

The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, Gq proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.[1]

See also[edit]


External links[edit]

  • "Prostanoid Receptors: EP1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.